27512-72-7

Basic information

• Product Name: Ethychlozate
• Synonyms: 5-chloro-1h-indazole-3-aceticaciethylester;ethyl-5-chloro-3(1h)-indazolylacetate;etychlozate;IZAA;figaron;Ethyl 5-chloro-1H-indazole-3-acetate;ETHYCHLOZATE;Ethychlozate PESTANAL
• CAS NO: 27512-72-7
• Molecular Formula: C11H11ClN2O2
• Molecular Weight: 238.67
• Mol File: 27512-72-7.mol
• Article Data: 4

Chemical Properties

• Melting Point: 77°C
• Boiling Point: 274 °C at 760 mmHg
• Flash Point: 119.5 °C
• Appearance: /
• Density: 1.3408 (rough estimate)
• Vapor Pressure: 0.00556mmHg at 25°C
• Refractive Index: 1.5500 (estimate)
• Storage Temp.: 0-6°C
• Solubility: DMSO (Slightly), Methanol (Slightly)
• PKA: 12.41±0.40(Predicted)
• CAS DataBase Reference: Ethychlozate(CAS DataBase Reference)
• NIST Chemistry Reference: Ethychlozate(27512-72-7)
• EPA Substance Registry System: Ethychlozate(27512-72-7)

Safety Data

• Hazard Codes: C
• Statements: 20-34
• Safety Statements: 26-36/37/39-45
• RIDADR: UN3263 8/PG 3
• WGK Germany: 3
• RTECS: NK7755000
• Hazardous Substances Data: 27512-72-7(Hazardous Substances Data)

Usage

General Description

Ethychlozate is a chemical compound that belongs to the class of chlorinated hydrocarbons. It is primarily used as a herbicide in agricultural settings to control grass and weed growth in crops. Ethychlozate is a non-selective herbicide, meaning it has the potential to kill a wide range of plant species. It works by disrupting the photosynthesis process in the target plants, ultimately leading to their death. However, due to its persistence in the environment and potential harmful effects on non-target organisms, the use of ethychlozate has been subject to regulatory restrictions and public concern. Studies have shown that it has the potential to accumulate in the environment and pose risks to aquatic ecosystems and human health. As a result, the use of ethychlozate has declined and alternatives with lower environmental impact are being explored.

InChI:InChI=1/C11H11ClN2O2/c1-2-16-11(15)6-10-8-5-7(12)3-4-9(8)13-14-10/h3-5H,2,6H2,1H3,(H,13,14)

Upstream product

• 63235-32-5 3-amino-3-(3-chloro-6-nitrophenyl)propionic acid 
• 6628-86-0 5-chloro-2-nitrobenzaldehyde 
• 64-17-5 ethanol 
• 27328-68-3 (5-Chloro-1H-indazol-3-yl)acetic acid 

Relevant articles and documents

Discovery of substituted indole derivatives as allosteric inhibitors of m6A-RNA methyltransferase, METTL3-14 complex

m6A RNA methyltransferase (METTL3-14) catalyzes the methylation of adenosine in mRNA and plays important roles in mRNA functions, and it has been implicated in the progression of multiple cancers, including acute myeloid leukemia (AML). In this study, we describe the discovery of the first allosteric inhibitor of the METTL3-14 complex based on structure–activity relationship (SAR) and optimization studies of the hit compound, 4-[2-[5-chloro-1-(diphenylmethyl)-2-methyl-1H-indol-3-yl]-ethoxy]benzoic acid (CDIBA). Compound 43n was optimized throughout the modifications of 4 different regions of the structure, and it displayed potent enzyme inhibitory activity of the METTL3-14 complex (IC50?=?2.81 μM) and an antiproliferative effect in the AML cell lines by suppressing the m6A level of mRNA. The inhibition mechanism and binding mode of 43n were based on the interaction of the reversible and noncompetitive inhibitory profile at the allosteric site along with selectivity for the METTL3-14 complex relative to each subunit enzyme or truncated complex enzyme.

Orally Active Aldose Reductase Inhibitors: Indazoleacetic, Oxopyridazineacetic, and Oxopyridopyridazineacetic Acid Derivatives

Benzothiazole side chains featured in zopolrestat (1a) and its congeners were incorporated into oxophthalazineacetic acid replacements, including indazole, pyridazinone, and pyridopyridazinone with a pendant acetic acid moiety.Potent aldose reductase inhi