27525-74-2

Basic information

• Product Name: dimethyl 2,6-dimethylpyridine-3,5-dicarboxylate
• Synonyms: dimethyl 2,6-dimethylpyridine-3,5-dicarboxylate;2,6-Dimethyl-3,5-pyridinedicarboxylic acid dimethyl ester
• CAS NO: 27525-74-2
• Molecular Formula: C₁₁H₁₃NO₄
• Molecular Weight: 223.22522
• EINECS: 248-509-9
• Mol File: 27525-74-2.mol
• Article Data: 42

Chemical Properties

• Melting Point: 101-102 °C
• Boiling Point: 275.4°Cat760mmHg
• Flash Point: 120.3°C
• Appearance: /
• Density: 1.168g/cm³
• Vapor Pressure: 0.00512mmHg at 25°C
• Refractive Index: 1.514
• PKA: 2.60±0.20(Predicted)
• CAS DataBase Reference: dimethyl 2,6-dimethylpyridine-3,5-dicarboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: dimethyl 2,6-dimethylpyridine-3,5-dicarboxylate(27525-74-2)
• EPA Substance Registry System: dimethyl 2,6-dimethylpyridine-3,5-dicarboxylate(27525-74-2)

Safety Data

• Hazardous Substances Data: 27525-74-2(Hazardous Substances Data)

Usage

Synthesis Reference(s)

Tetrahedron Letters, 34, p. 6033, 1993 DOI: 10.1016/S0040-4039(00)61720-3

InChI:InChI=1/C11H13NO4/c1-6-8(10(13)15-3)5-9(7(2)12-6)11(14)16-4/h5H,1-4H3

Upstream product

• 1153-66-8 3,5-diethoxycarbonyl-2,6-dimethyl-4-ethyl-1,4-dihydropyridine 
• 17438-14-1 2,6-dimethyl-3,5-dimethoxycarbonyl-1,4-dihydropyridine 
• 2564-83-2 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical 
• 67-56-1 methanol 
• 105-45-3 acetoacetic acid methyl ester 
• 91353-50-3 2,4-diacetylpentanedioic acid dimethyl ester 
• 68-12-2 N,N-dimethyl-formamide 
• 872-50-4 1-methyl-pyrrolidin-2-one 
• 127-19-5 N,N-dimethyl acetamide 
• 67-68-5 dimethyl sulfoxide 
• 111462-14-7 1,4-dihydro-2,6-dimethyl-4-ethyl-3,5-pyridinedicarboxylic acid dimethyl ester 
• 55536-69-1 2,4,6-Trimethyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid dimethyl ester 
• 50-00-0 formaldehyd 
• 121195-86-6 4-isobutyl-3,5-dimethoxycarbonyl-2,6-dimethyl-1,4-dihydropyridine 

Downstream Products

• 89399-06-4 C₁₈H₂₀N₃⁽¹⁺⁾*C₉H₁₁O₃S^(1-) 
• 89399-10-0 C₁₈H₂₀N₃⁽¹⁺⁾*C₉H₁₁O₃S^(1-) 
• 89398-89-0 N,N'-dimethyl 5,12-diaza<2₄>(1,2,4,5)cyclophanebis(onium) bis(p-toluenesulfonate) 
• 89398-91-4 N,N'-dimethyl 5,15-diaza<2₄>(1,2,4,5)cyclophanebis(onium) bis(p-toluenesulfonate) 
• 77825-10-6 3-carbomethoxy-5-(chloromethyl)-2,6-dimethylpyridine 
• 591770-02-4 2,6-dimethyl-3,5-bis[di(1-methyl-2-imidazolyl)(3-cyanobenzyloxy)methyl]pyridine 

Relevant articles and documents

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The invention discloses a method for synthesizing pyridine and derivatives thereof by catalyzing a Hass ester 1, 4-dihydropyridine compound through titanocene dichloride, the dihydropyridine structure of the Hass ester 1, 4-dihydropyridine compound has a certain aromatic ring driving force and is easily oxidized into a pyridine structure, and the the Hass ester 1, 4- dihydropyridine and the derivative thereof are subjected to oxidative conversion to generate the pyridine and the derivative thereof by taking titanocene dichloride as a catalyst, so that a simple way for preparing the pyridine and the derivative thereof is provided. The method is mild in reaction condition, simple to operate, short in reaction time, single in reaction product and high in atom economy, and only the product needs to be subjected to simple column chromatography separation after the reaction is finished. The Hanss ester 1, 4-dihydropyridine and the derivative thereof obtained by the invention have wide biological activity and medicinal value.