2756-85-6 Usage
Description
1-Amino-1-cyclohexanecarboxylic acid, also known as α-Aminocyclohexanecarboxylic Acid, is an alpha-amino acid that features a cyclohexanecarboxylic acid structure with an amino group substitution at the 1st position. It is a white powder in its chemical form and is known for its ability to enhance the stability of highly regular β-helical motifs.
Uses
1. Used in Pharmaceutical Industry:
1-Amino-1-cyclohexanecarboxylic acid is used as a building block for the synthesis of various pharmaceutical compounds due to its unique structure and ability to stabilize β-helical motifs. This property makes it a valuable component in the development of new drugs with improved efficacy and selectivity.
2. Used in Chemical Synthesis:
1-Amino-1-cyclohexanecarboxylic acid is used as an intermediate in the chemical synthesis of various organic compounds, particularly those with cyclohexane-based structures. Its versatility in forming stable β-helical motifs allows for the creation of a wide range of molecules with diverse applications.
3. Used in Material Science:
In the field of material science, 1-Amino-1-cyclohexanecarboxylic acid can be utilized as a component in the development of novel materials with enhanced structural properties. Its ability to stabilize β-helical motifs can contribute to the creation of materials with improved mechanical strength and stability.
4. Used in Research and Development:
1-Amino-1-cyclohexanecarboxylic acid serves as an important research tool in the study of protein folding, stability, and structure. Its unique properties make it a valuable compound for understanding the underlying mechanisms of protein interactions and the development of new therapeutic strategies.
Check Digit Verification of cas no
The CAS Registry Mumber 2756-85-6 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,7,5 and 6 respectively; the second part has 2 digits, 8 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 2756-85:
(6*2)+(5*7)+(4*5)+(3*6)+(2*8)+(1*5)=106
106 % 10 = 6
So 2756-85-6 is a valid CAS Registry Number.
InChI:InChI=1/C6H12N2O2/c7-6(5(9)10)1-3-8-4-2-6/h8H,1-4,7H2,(H,9,10)
2756-85-6Relevant articles and documents
Synthesis and Anticonvulsant Activity of Substituted-1,3-diazaspiro[4.5]decan-4-ones
Aboul-Enein, Mohamed Nabil,El-Azzouny, Aida Abdel Sattar,Saleh, Ola Ahmed,Amin, Kamilia Mahmoud,Maklad, Yousreya Ali,Hassan, Rasha Mohamed
, p. 575 - 588 (2015/08/11)
A series of novel spiroimidazolidinone derivatives 6a-d and 8a-x were synthesized and biologically evaluated for their anticonvulsant activity in the maximal electroshock seizure (MES) assay and the subcutaneous pentylenetetrazole (scPTZ) screening test. Compound 8w was the most active derivative in the scPTZ screening test with an ED50 value by about 5- and 83.6-fold lower than those of phenobarbital and ethosuximide as reference drugs, respectively. Most of the tested compounds exhibited moderate to weak activity in the MES screen test, except for 8a which displayed 100% protection at 0.09 mmol/kg. Moreover, all the test compounds did not show any minimal motor impairment in the neurotoxicity test.
Two methods for spirothiohydantoin synthesis
Stoyanov, Neyko,Marinov, Marin
, p. 680 - 685,6 (2020/08/24)
Two methods for spirothiohydantoin synthesis are presented. The title compounds were prepared with reaction of the corresponding 1- aminocycloalkanecarboxylic acids and thiourea. These compounds were also prepared by a hydrolysis of the relevant spirodithiohydantoins with barium hydroxide. The structures of the compounds obtained were verified by comparison of 1H, and 13C NMR, IR and MS spectral data.
Microwave-assisted synthesis of cycloalkanespirohydantoins and piperidinespirohydantoins as precursors of restricted α-amino acids
Rivero, Ignacio A.,Reynoso-Soto, Edgar A.,Ochoa-Teran, Adrian
experimental part, p. 260 - 271 (2011/05/13)
Cycloalkanespirohydantoins 3 and piperidinespirohydantoins 4 were synthesized from cycloalkanones 9 and piperidones 10 under microwave-assisted conditions. Results are compared with those obtained under thermal conditions. Cycloalkanespirohydantoins 3 were N-protected with Boc group and hydrolyzed under basic conditions to obtain five, six and seven-membered ring restricted α-amino acids 12 in very good overall yields (76-94%). ARKAT USA, Inc.
