2757-83-7Relevant articles and documents
Oxidation chemistry of 3,7-dimethylxanthine - A central behavioural stimulant at solid electrodes
Goyal, Rajendra N.,Rastogi, Arshi
, p. 495 - 509 (2007/10/03)
The electrochemical oxidation of 3,7-dimethylxanthine has been studied in the pH range 2.1-10.7 at pyrolytic graphite, platinum and glassy carbon electrodes. The electrooxidation of 3,7-dimethylxanthine at solid electrodes proceeds in a single 4e, 4H+ pH dependent step to give a diimine species which decomposes in chemical followup steps. The UV absorbing intermediate generated during electrooxidation of 3,7-dimethylxanthine decayed approximately at the same rate as that of xanthine and followed the first order kinetics. The products of electrooxidation of 3,7-dimethylxanthine were characterized and a reaction scheme is suggested to explain their formation. The effect of introducing methyl groups into the electrooxidation of xanthine is also presented.
Electrochemical and peroxidase catalysed oxidation of 1,7-dimethyluric acid and effect of methyl groups on the oxidation mechanism
Goyal, Rajendra N.,Jain, Ajay K.,Jain, Neena
, p. 1153 - 1160 (2007/10/03)
The electrochemical oxidation of 1,7-dimethyluric acid has been studied over a wide pH range of 2.2-10.3 at solid electrodes.Based on the results obtained from linear and cyclic sweep voltammetry, coulometry, spectroscopic studies and various analytical studies, a reaction mechanism has been proposed.The enzymatic oxidation of 1,7-dimethyluric acid has also been found to follow an identical pathway.The products of oxidation have been separated and characterized by using mp, 1H NMR and mass spectra.N-Methylation of the pyrimidine ring of purine causes protonation of nitrogen and affects the oxidation mechanism by not permitting the ring contraction of the diol intermediate.
Comparison of Electrochemical and Enzymic Oxidation of 3-Methyluric Acid
Goyal, Rajendra N.,Verma, Madhu Shri
, p. 1241 - 1248 (2007/10/02)
The electrochemical oxidation of 3-methyluric acid has been studied in the pH range 3.2-11.3 at pyrolytic graphite and glassy carbon electrodes.The conjugate base is the species oxidized over the whole pH range studied.Intermediates generated have been characterized in terms of their UV spectra and kinetics of decay, and products have been separated and characterized.The intermediates, formed and spectral and kinetics studies, during the peroxidase-catalysed oxidation of 3-methyluric acid indicated identical behaviour to that observed in electrochemical oxidation.It has thus been concluded that the electrochemical and enzymic oxidation of 3-methyluric acid proceed by an identical EC mechanism.