275801-69-9Relevant articles and documents
Synthesis of a cyanopeptide-analogue with trypsin activating properties
Radau, Gregor,Rauh, Daniel
, p. 779 - 781 (2000)
An efficient synthesis of a peptidic analogue of cyanobacterial metabolites with proposed serine protease inhibitory activity has been developed. Surprisingly, one trypsin activating compound was obtained. (C) 2000 Elsevier Science Ltd. All rights reserved.
Cyanopeptide analogues: New lead structures for the design and synthesis of new thrombin inhibitors
Radau, Gregor,Stuerzebecher
, p. 729 - 732 (2007/10/03)
This contribution deals with the structure-based design and syntheses of the new serine protease inhibitors RA-1001 and RA-1002, which are analogues of the blue-green algae derived cyanopeptide aeruginosin 98-B. Both compounds inhibit thrombin with Ki values of 5.6 μM and 8.7 μM, respectively.