2759-55-9

Basic information

• Product Name: N-(4-methylphenyl)propanamide
• Synonyms: N-(4-Methylphenyl)propanamide; propanamide, N-(4-methylphenyl)-
• CAS NO: 2759-55-9
• Molecular Formula: C₁₀H₁₃NO
• Molecular Weight: 163.2163
• Mol File: 2759-55-9.mol
• Article Data: 33

Chemical Properties

• Boiling Point: 319.8°C at 760 mmHg
• Flash Point: 187.1°C
• Density: 1.051g/cm³
• Vapor Pressure: 0.000331mmHg at 25°C
• Refractive Index: 1.556
• CAS DataBase Reference: N-(4-methylphenyl)propanamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-methylphenyl)propanamide(2759-55-9)
• EPA Substance Registry System: N-(4-methylphenyl)propanamide(2759-55-9)

Safety Data

• Hazardous Substances Data: 2759-55-9(Hazardous Substances Data)

Upstream product

• 624-31-7 4-tolyl iodide 
• 79-05-0 Propionamid 
• 22133-59-1 4-Methylmercapto-N-propionyl-anilin 
• 75-16-1 methylmagnesium bromide 
• 10508-09-5 di-tert-amyl peroxide 
• 7175-47-5 4-methylphenyl isocyanide 
• 99-99-0 1-methyl-4-nitrobenzene 
• 802294-64-0 propionic acid 
• 106-49-0 p-toluidine 
• 79-03-8 propionyl chloride 
• 7424-54-6 3,5-heptanedione 
• 609-08-5 Diethyl methylmalonate 
• 501-60-0 1,2-di(p-tolyl)diazene 
• 123-62-6 propionic acid anhydride 

Downstream Products

• 1638490-74-0 4-phenyl-1-p-tolylquinolin-2(1H)-one 
• 6876-59-1 N-(4-methylphenyl)-cyclohexanecarboxamide 
• 132118-28-6 2-chloro-3,6-dimethylquinoline 
• 79489-69-3 N¹,N¹-Diethyl-N²-(p-tolyl)propionamidine 
• 79489-64-8 2-Diethylamino-3,6-dimethylquinoline 
• 77486-49-8 N'-(4-methylphenyl)-N,N-dipropylpropionamidine 
• 103753-48-6 propionic acid-(N-chloro-p-toluidide) 

Relevant articles and documents

CATALYST FOR CONVERTING ESTER TO AMIDE USING HYDROXYL GROUP AS ORIENTATION GROUP

Provided is a method for amidating a hydroxy ester compound at a high chemical selectivity. The amidation reaction method for a hydroxy ester compound comprises, in the presence of a catalyst containing a compound of a transition metal of the group 4 or group 5 in the periodic table, reacting at least one kind of hydroxy ester compound selected from the group consisting of an α-hydroxy ester compound, a β-hydroxy ester compound, a γ-hydroxy ester compound and a δ-hydroxy ester compound with an amino compound so as to amidate an ester group having a hydroxyl group at the α-, β-, γ- or δ-position of the hydroxy ester compound.

Iodine and Br?nsted acid catalyzed C–C bond cleavage of 1,3-diketones for the acylation of amines

A metal-free N-acylation method of anilines with 1,3-diketones has been developed, by using iodine and p-toluene sulfonic acid as the co-catalysts. The reaction can proceed in 1,4-dioxane at elevated temperature to produce the corresponding amides with 48–89% yields. Further, the gram-scale experiment was carried out under the standard conditions and the possible mechanism was proposed.

SO2F2-Activated Efficient Beckmann Rearrangement of Ketoximes for Accessing Amides and Lactams

A novel, mild and practical protocol for the efficient activation of the Beckmann rearrangement utilizing the readily available and economical sulfuryl fluoride (SO2F2 gas) has been developed. The substrate scope of the operationally simple methodology has been demonstrated by 37 examples with good to nearly quantitative isolated yields (over 90 % yield in most cases) in a short time, including B(OH)2, COOH, NH2, and OH substituted substrates. A tentative mechanism was proposed involving formation and elimination of key intermediate, sulfonyl ester.