27602-76-2 Usage
Description
2-(6-methoxy-2-naphthyl)propanal oxime is an organic compound that is characterized by its oxime functional group and a naphthyl moiety with a methoxy substituent. It is an impurity found in the synthesis of Naproxen, a well-known non-steroidal anti-inflammatory drug (NSAID) used for its analgesic and antipyretic properties.
Uses
Used in Pharmaceutical Industry:
2-(6-methoxy-2-naphthyl)propanal oxime is used as an impurity in the production of Naproxen (N377525), an anti-inflammatory, analgesic, and antipyretic agent. Its presence, although as an impurity, is significant in the synthesis process of Naproxen, which is a widely used NSAID for treating various conditions such as pain, inflammation, and fever.
As an impurity, it is essential to monitor and control the levels of 2-(6-methoxy-2-naphthyl)propanal oxime in the final Naproxen product to ensure safety, efficacy, and quality standards are met. The pharmaceutical industry relies on stringent quality control measures to minimize the presence of impurities like this oxime compound in the final drug formulation.
Check Digit Verification of cas no
The CAS Registry Mumber 27602-76-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,7,6,0 and 2 respectively; the second part has 2 digits, 7 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 27602-76:
(7*2)+(6*7)+(5*6)+(4*0)+(3*2)+(2*7)+(1*6)=112
112 % 10 = 2
So 27602-76-2 is a valid CAS Registry Number.
27602-76-2Relevant articles and documents
Method for preparing naproxen intermediate
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, (2020/12/08)
A technical scheme of the invention provides a method for preparing a naproxen intermediate represented by a chemical structural formula I. Preparation reactions are as follows: 6-methoxy-2-acetonaphthone and trimethyl sulfonium hydrogen sulfate are subjected to an epoxidation reaction in the presence of alkali so as to prepare 2-(6-methoxynaphthyl)-1,2-epoxypropane, the 2-(6-methoxynaphthyl)-1,2-epoxypropane is subjected to catalyzed rearrangement through silica gel or FeCl3 and then reacts with hydroxylamine hydrochloride, thereby preparing an intermediate, i.e., 2-(6-methoxy-2-naphthyl)propyl oxime (I) in one step. Naproxen is prepared by employing a one-pot method through a key intermediate, i.e., 2-(6-methoxy-2-naphthyl)propyl oxime.
