27602-80-8Relevant articles and documents
Identification of glutathione and related cysteine conjugates derived from reactive metabolites of methyleugenol in rats
Yao, Huina,Peng, Ying,Zheng, Jiang
, p. 143 - 152 (2016)
Methyleugenol (ME), an alkenylbenzene compound, is a constituent of many foods and is used as flavoring agent in foodstuffs and as fragrance in cosmetics. It has been reported that exposure to ME can cause carcinogenicity, cytotoxicity, and genotoxicity.
A convenient synthesis of 1-aryl-2-propanone precursors of α-methyldopa
An,D'Aloisio,Venturello
, p. 1229 - 1231 (1992)
A simple two-step approach to 1-(3,4-dimethoxyphenyl)- and 1-[3,4-(methylenedioxy)phenyl]-2-propanone (4a and 4b), useful intermediates for α-methyldopa, is described. It is based on the epoxidation of the widely available methyleugenol (1-allyl-3,4-dimethoxybenzene, 1a) and safrole [1-allyl-3,4-(methylenedioxy)benzene, 1b] with hydrogen peroxide catalyzed by tungsten peroxo complex 2a under two-phase conditions, followed by isomerization of the intermediate epoxides 3a and 3b by lithium iodide.
Prilezhaev dihydroxylation of olefins in a continuous flow process
Van Den Broek, Bas A. M. W.,Becker, René,K?ssl, Florian,Delville, Mari?lle M. E.,Nieuwland, Pieter J.,Koch, Kaspar,Rutjes, Floris P. J. T.
experimental part, p. 289 - 292 (2012/06/01)
Epoxidation of both terminal and non-terminal olefins with peroxy acids is a well-established and powerful tool in a wide variety of chemical processes. In an additional step, the epoxide can be readily converted into the corresponding trans-diol. Batch-wise scale-up, however, is often troublesome because of the thermal instability and explosive character of the peroxy acids involved. This article describes the design and semi-automated optimization of a continuous flow process and subsequent scale-up to preparative production volumes in an intrinsically safe manner. Olefins go with the flow: Prilezhaev dihydroxylation can be performed on a large scale in continuous flow microreactor systems in the oxidation of terminal and internal olefins. Major drivers for a continuous flow process include better control, improved safety, and a faster overall process, leading to a significantly higher throughput. Copyright