276890-57-4

Basic information

• Product Name: 4-(N-ETHYL-N-4-HYDROXYBUTYL)AMINO-2,5,6-TRIMETHYL-7-(2,4,6-TRIMETHYLPHENYL)PYRROLO[2,3-D]PYRIMIDINE HYDROCHLORIDE
• Synonyms: LWH-63 HYDROCHLORIDE;4-(N-ETHYL-N-4-HYDROXYBUTYL)AMINO-2,5,6-TRIMETHYL-7-(2,4,6-TRIMETHYLPHENYL)PYRROLO[2,3-D]PYRIMIDINE HYDROCHLORIDE;NIH-3;NIH-3, 4-(N-Ethyl-n-4-hydroxybutyl)amino-2,5,6-trimethyl-7-(2,4,6-trimethylphenyl)pyrrolo[2,3-d]pyrimidine hydrochloride
• CAS NO: 276890-57-4
• Molecular Formula: C₂₄H₃₄N₄O
• Molecular Weight: 431.01
• Mol File: 276890-57-4.mol
• Article Data: 3

Chemical Properties

• Appearance: light brown/solid
• Storage Temp.: 2-8°C
• Solubility: DMSO: ~10 mg/mL
• CAS DataBase Reference: 4-(N-ETHYL-N-4-HYDROXYBUTYL)AMINO-2,5,6-TRIMETHYL-7-(2,4,6-TRIMETHYLPHENYL)PYRROLO[2,3-D]PYRIMIDINE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(N-ETHYL-N-4-HYDROXYBUTYL)AMINO-2,5,6-TRIMETHYL-7-(2,4,6-TRIMETHYLPHENYL)PYRROLO[2,3-D]PYRIMIDINE HYDROCHLORIDE(276890-57-4)
• EPA Substance Registry System: 4-(N-ETHYL-N-4-HYDROXYBUTYL)AMINO-2,5,6-TRIMETHYL-7-(2,4,6-TRIMETHYLPHENYL)PYRROLO[2,3-D]PYRIMIDINE HYDROCHLORIDE(276890-57-4)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 276890-57-4(Hazardous Substances Data)

Upstream product

• 42042-64-8 N-ethyl-4-hydroxybutanamide 
• 39216-86-9 4-(ethylamino)butan-1-ol 
• 299948-98-4 (Z)-4-ethylaminobut-2-en-1-ol 
• 299949-01-2 (Z)-4-[ethyl[2,5,6-trimethyl-7-(2,4,6-trimethylphenyl)pyrrolo[2,3-d]pyrimidin-4-yl]amino]but-2-en-1-ol 

Relevant articles and documents

Synthesis of [3H]-labelled 4-[ethyl[2,5,6-trimethyl-7-(2,4,6- trimethylphenyl)pyrrolo[2,3-d]pyrimidin-4-yl]amino]-2,3-[3H]-butan-1- ol: A high affinity radioligand for the corticotropin-releasing hormone type 1 receptor

[3H]-Labelled 4-[ethyl[2,5,6-trimethyl-7-(2,4,6-trimethylphenyl) pyrrolo[2,3-d]pyrimidin-4-yl]amino]-2,3-[3H]-butan-1-ol (3b) was prepared as a novel non-peptidic radiolabelled high affinity antagonist of the corticotropin-releasing

Synthesis and biological activity of fluoro-substituted pyrrolo[2,3-d]pyrimidines: The development of potential positron emission tomography imaging agents for the corticotropin-releasing hormone type 1 receptor

A series of fluoro-substituted 4-(diakylamino)pyrrolo[2,3-d]pyrimidines was synthesized and their binding affinity for corticotropin-releasing hormone type 1 receptor (CRHR1) was investigated. Compounds 11a and 11b possessed very high CRHR1 affinity (K(i) = 3.5, 0.91 nM, respectively). They are promising candidates for the development of 18F-containing nonpeptide PET radioligands for CRHR1. Published by Elsevier Science Ltd.