2770-15-2Relevant articles and documents
Metal-free transamidation of benzoylpyrrolidin-2-one and amines under aqueous conditions
Joseph, Devaneyan,Lee, Sunwoo,Park, Myeong Seong
supporting information, p. 6227 - 6232 (2021/07/28)
N-Acyl lactam amides, such as benzoylpyrrolidin-2-one, benzoylpiperidin-2-one, and benzoylazepan-2-one reacted with amines in the presence of DTBP and TBAI to afford the transamidated products in good yields. The reactions were conducted under aqueous conditions and good functional group tolerance was achieved. Both aliphatic and aromatic primary amines displayed good activity under metal-free conditions. A radical reaction pathway is proposed.
Novel aryl ether derivatives as antiinflammatory and analgesics
Rashmi,Rao, Gopal Krishna,Devi, Kshama,Shivananda,Swetha,Ga, Suneetha
, p. 1401 - 1407 (2012/06/29)
The diaryl ether moieties have attracted considerable attention of medicinal chemists as they are endowed with a wide range of diverse biological activities. The present study involves synthesis, characterization of some new aryl ethers and evaluation of their antiinflammatory and analgesic activity. A series of new aryl ether derivatives [4(a-h), 5] were prepared by Ullmann's ether condensation. The structures of new compounds are supported by their IR, 1H NMR and Mass spectra. The new derivatives were evaluated for their antiinflammatory and analgesic activity. Among the tested, compound 3 has shown better antiinflammatory and analgesic activity.
N-(ortho-Aryloxyphenyl)arylimidoyl Radicals: Novel 1,5-Aryl Radical Translocation from Oxygen to Carbon
Guidotti, Simona,Leardini, Rino,Nanni, Daniele,Pareschi, Patrizia,Zanardi, Giuseppe
, p. 451 - 454 (2007/10/02)
Imidoyl radicals 4a-d, obtained by hydrogen abstraction from imines 1a-d, give 7-membered cyclisation leading to oxazapines 2a-d.The intermediate spirocyclohexadienyl radicals of the competitive 6-membered ring closure (6a-d) rearrange to aryloxy radicals , giving benzophenones 3a-d: the whole process entails a novel 1,5-aryl radical translocation from an oxygen to a carbon atom.