27746-02-7

Basic information

• Product Name: 4-BROMOPYRROLE-2-CARBOXYLIC ACID
• Synonyms: 4-BROMO-1H-PYRROLE-2-CARBOXYLIC ACID;4-BROMOPYRROLE-2-CARBOXYLIC ACID;RARECHEM AL BE 1264;4-bromo-1H-pyrrole-2-carboxylic acid(SALTDATA: FREE);4-Bromo-1H-pyrrol-2-carboxylic acid
• CAS NO: 27746-02-7
• Molecular Formula: C₅H₄BrNO₂
• Molecular Weight: 189.99
• Product Categories: pharmacetical
• Mol File: 27746-02-7.mol
• Article Data: 5

Chemical Properties

• Melting Point: 168-170°C
• Boiling Point: 393 °C at 760 mmHg
• Flash Point: 191.5 °C
• Appearance: /
• Density: 1.969 g/cm³
• Vapor Pressure: 6.98E-07mmHg at 25°C
• Refractive Index: 1.652
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 4.06±0.10(Predicted)
• CAS DataBase Reference: 4-BROMOPYRROLE-2-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 4-BROMOPYRROLE-2-CARBOXYLIC ACID(27746-02-7)
• EPA Substance Registry System: 4-BROMOPYRROLE-2-CARBOXYLIC ACID(27746-02-7)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 27746-02-7(Hazardous Substances Data)

Usage

General Description

4-Bromopyrrole-2-carboxylic acid, also known as 1H-pyrrole-2-carboxylic acid, is a chemical compound that belongs to the class of pyrrole derivatives. It is a white to off-white solid with a molecular formula of C5H4BrNO2. 4-BROMOPYRROLE-2-CARBOXYLIC ACID is commonly used in organic synthesis and medicinal chemistry, and it has been reported to exhibit anti-inflammatory and antifungal activities. Its structure consists of a benzene ring fused to a five-membered pyrrole ring with a carboxylic acid group attached to the carbon atom in the pyrrole ring. 4-Bromopyrrole-2-carboxylic acid is an important building block for the synthesis of various pharmaceuticals and agrochemicals.

InChI:InChI=1/C5H4BrNO2/c6-3-1-4(5(8)9)7-2-3/h1-2,7H,(H,8,9)/p-1

Upstream product

• 72652-32-5 1-(4-bromo-1H-pyrrol-2-yl)-2,2,2-trichloroethanone 
• 35302-72-8 pyrrol-2-yl trichloromethyl ketone 
• 1057111-70-2 C₁₄H₁₁BrF₆N₂O₄ 

Downstream Products

• 1069472-63-4 4-bromo-N-(3-bromo-4-methoxyphenethyl)-1H-pyrrole-2-carboxamide 
• 1174650-73-7 4-bromo-N-(3-bromo-4-(2-(pyrrolidin-1-yl)ethoxy)phenethyl)-1H-pyrrole-2-carboxamide 
• 1069472-64-5 4-bromo-N-(3-bromo-4-hydroxyphenethyl)-1H-pyrrole-2-carboxamide 
• 934995-58-1 Dispyrin 
• 1338811-32-7 4-bromo-N-(2,4-dimethoxybenzyl)-N-(3-(4-nitrophenyl)prop-2-ynyl)-1H-pyrrole-2-carboxamide 
• 1338811-18-9 4-bromo-N-(3-(3-cyano-4-fluorophenyl)prop-2-ynyl)-N-(2,4-dimethoxybenzyl)-1H-pyrrole-2-carboxamide 

Relevant articles and documents

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MELANIN CONCENTRATING HORMONE RECEPTOR-1 ANTAGONISTS

The present application provides compounds, including all stereoisomers, solvates, prodrugs and pharmaceutically acceptable forms thereof according to Formula I wherein R1a, R1b, R1c, Q, A, R3, W, D and R2 are defined herein. Additionally, the present application provides pharmaceutical compositions containing at least one compound according to Formula I and optionally at least one additional therapeutic agent. Finally, the present application provides methods for treating a patient suffering from an MCHR-1 modulated disease or disorder such as, for example, obesity, diabetes, depression or anxiety by administration of a therapeutically effective dose of a compound according to Formula I.

Damipipecolin and damituricin, novel bioactive bromopyrrole alkaloids from the Mediterranean sponge Axinella damicornis

Two new bromopyrrole alkaloids, damipipecolin (1) and damituricin (2), have been isolated from the Mediterranean sponge Axinella damicornis, and their structures established through spectroscopic methods. Compounds 1 and 2 extend the structural variety of