27844-07-1

Basic information

• Product Name: N-Trimethylsilyl-L-alanine trimethylsilyl ester
• Synonyms: N-Trimethylsilyl-L-alanine trimethylsilyl ester
• CAS NO: 27844-07-1
• Molecular Formula: C₉H₂₃NO₂Si₂
• Molecular Weight: 233.46
• Mol File: 27844-07-1.mol
• Article Data: 14

Chemical Properties

• Boiling Point: 201.1°C at 760 mmHg
• Flash Point: 75.4°C
• Appearance: /
• Density: 0.893g/cm³
• Vapor Pressure: 0.314mmHg at 25°C
• Refractive Index: 1.422
• PKA: 9.74±0.70(Predicted)
• CAS DataBase Reference: N-Trimethylsilyl-L-alanine trimethylsilyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: N-Trimethylsilyl-L-alanine trimethylsilyl ester(27844-07-1)
• EPA Substance Registry System: N-Trimethylsilyl-L-alanine trimethylsilyl ester(27844-07-1)

Safety Data

• Hazardous Substances Data: 27844-07-1(Hazardous Substances Data)

Usage

InChI:InChI=1/C9H23NO2Si2/c1-8(10-13(2,3)4)9(11)12-14(5,6)7/h8,10H,1-7H3

Upstream product

• 56-41-7 L-alanin 
• 27607-77-8 trimethylsilyl trifluoromethanesulfonate 
• 25561-30-2 N,O-Bis(trimethylsilyl)trifluoroacetamide 
• 4744-12-1 (S)-α-alanine 
• 999-97-3 1,1,1,3,3,3-hexamethyl-disilazane 
• 75-77-4 chloro-trimethyl-silane 

Downstream Products

• 80514-65-4 Trt-Ala*Et2NH 
• 169393-80-0 Fmoc-Asp(OBn)-Ala-OH 
• 182485-55-8 PhAcOZ-Ala-OH 
• 160422-19-5 2-(4-nitrophenylsulfonyl)ethoxycarbonyl-Ala-OH (Nsc-Ala-OH) 
• 1238891-58-1 C₁₂H₁₆N₂O₄Si 
• 1137543-05-5 C₂₀H₂₉N₃O₇ 
• 1137543-09-9 C₁₈H₂₇N₃O₆ 
• 1051456-48-4 Boc-Phe-ψ(NH-CO-NH)-Ala-OH 

Relevant articles and documents

Synthesis of (S)-2-[(dioctylphosphoryl)methylamino]propionic acid from trimethylsilyl 2-(trimethylsilylamino)propanoate

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Simple and rapid synthesis of Nα-urethane protected β-amino alcohols and peptide alcohols employing HATU

The activation of the Nα--urcihanc protected (Fmoc-/Boc-/Z-/Bsmoc) α-amino acids employing l-[bis(dimethylamino)- methylene]-lH-l,2,3-triazolo-[4,5-6]pyridinium.0hexa-flurophosphate-3-oxide (HATU) followed by reduction of the in situ generated -OAt ester with NaBH 4 results in the corresponding ss-amino alcohols in good yields. This synthesis is the first demonstration of the application of the efficient coupling agent HATU for practical synthesis of ss-amino alcohols. The protocol is general for all common N-protecting groups including the highly base sensitive Bsmoc group. The protocol has also been successfully extended for the synthesis of peptide alcohols.

HOBt·DCHA-mediated synthesis of sterically hindered peptides employing Fmoc-amino acid chlorides in both solution-phase and solid phase methods

The synthesis of peptides employing Fmoc-amino acid chlorides in presence of HOBt·DCHA salt in solution as well as by the solid-phase methods is described. The coupling was found to be complete in 30 min and free from racemization. The synthesis of β-casomorphin by solid-phase protocol employing Fmoc-amino acid chloride/HOBt·DCHA in DMF-CH2Cl2 has also been outlined. The final peptide was obtained in 80% yield and was fully characterized. Copyright Taylor & Francis Group, LLC.