27904-66-1

Basic information

• Product Name: 2(3H)-Benzofuranone, 5-chloro-3-phenyl-
• Synonyms: 5-chloro-3-phenyl-1-benzofuran-2(3H)-one;5-chloro-3-phenyl-3H-benzofuran-2-one;5-chloro-2,3-dihydro-2-oxo-3-phenylbenzofuran;5-Chlor-3-phenyl-3H-benzofuran-2-on;5-chloro-3-phenyl-2(3H)-benzofuranone
• CAS NO: 27904-66-1
• Molecular Formula: C14H9ClO2
• Molecular Weight: 244.677
• Mol File: 27904-66-1.mol
• Article Data: 5

Chemical Properties

• Melting Point: 124 °C
• Boiling Point: 338.9±41.0 °C(Predicted)
• Density: 1.342±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 2(3H)-Benzofuranone, 5-chloro-3-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 2(3H)-Benzofuranone, 5-chloro-3-phenyl-(27904-66-1)
• EPA Substance Registry System: 2(3H)-Benzofuranone, 5-chloro-3-phenyl-(27904-66-1)

Safety Data

• Hazardous Substances Data: 27904-66-1(Hazardous Substances Data)

Usage

Class

Synthetic organic compound, benzofuranones

Structure

Benzene ring attached to a furan ring with a chlorine atom at the 5th position and a phenyl group at the 3rd position

Usage

Pharmaceutical and chemical industries for the synthesis of drugs and agrochemicals, potential biological activities (anti-inflammatory and anti-cancer properties), building block in the synthesis of other complex organic molecules.

Upstream product

• 106-48-9 4-chloro-phenol 
• 611-71-2 MANDELIC ACID 

Downstream Products

• 1314114-29-8 1-[(3R)-5-chloro-2,3-dihydro-2-oxo-3-phenyl-3-benzofuranyl]-1,2-hydrazinedicarboxylic acid,1,2-bis(phenylmethyl) ester 
• 85-19-8 (5-chloro-2-hydroxyphenyl)phenylmethanone 
• 1417999-23-5 (R)-methyl 3-(4-bromophenyl)-5-((S)-((S)-5-chloro-2-oxo-3-phenyl-2,3-dihydrobenzofuran-3-yl)(phenyl)methyl)-4,5-dihydroisoxazole-5-carboxylate 

Relevant articles and documents

Nickel-Catalyzed Decarbonyloxidation of 3-Aryl Benzofuran-2(3H)-ones to 2-Hydroxybenzophenones

We have developed a protocol to facilitate the nickel-catalyzed decarbonyloxidation of 3-aryl benzofuran-2(3H)-ones to 2-hydroxybenzophenones under mild conditions, which is an efficient approach for the decarbonyloxidation of lactones in organic synthesis. A diverse range of substrates can undergo C(O)-O/C(O)-C bond cleavage to generate the target products in good yields. These 2-hydroxybenzophenones can be converted into a variety of compounds via reactions such as esterification, cyclization, and reduction.

Recyclable nickel-catalyzed C-H/O-H dual functionalization of phenols with mandelic acids for the synthesis of 3-aryl benzofuran-2(3: H)-ones under solvent-free conditions

Herein, we developed a protocol for the efficient synthesis of 3-aryl benzofuran-2(3H)-ones under solvent-free conditions from phenols and mandelic acids using Ni(OTf)2 as a catalyst. A diverse range of mandelic acids and phenols undergo C-H/O-

Synthesis and pharmacological activities of new 3-phenyl-3(N,N-substituted aminomethyl)-2(3H)-benzofuranones

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