280107-25-7Relevant articles and documents
Diastereoselective synthesis of (5R,7R)- and (5R,7S)-5,7-dimethyl-6,7- dihydro-5H-dibenz[c,e]azepines
Saudan, Lionel A.,Bernardinelli, Gérald,Kündig, E. Peter
, p. 483 - 486 (2007/10/03)
Starting from (R)-1-(2-methoxyphenyl)ethylamine, the title compounds were synthesized. Key steps are a diastereoselective imine alkylation and a Pd-catalyzed biaryl coupling. The benzylic stereogenic centers of the (5R,7R)-azepine induce a strong bias for