28023-90-7

Basic information

• Product Name: 4'-Chloro-3-biphenylol
• Synonyms: 4'-Chloro-3-biphenylol;4-chloro-3'-hydroxybiphenyl
• CAS NO: 28023-90-7
• Molecular Formula: C₁₂H₉ClO
• Molecular Weight: 204.65
• Mol File: 28023-90-7.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 361.5°Cat760mmHg
• Flash Point: 172.5°C
• Appearance: /
• Density: 1.239g/cm³
• CAS DataBase Reference: 4'-Chloro-3-biphenylol(CAS DataBase Reference)
• NIST Chemistry Reference: 4'-Chloro-3-biphenylol(28023-90-7)
• EPA Substance Registry System: 4'-Chloro-3-biphenylol(28023-90-7)

Safety Data

• Hazardous Substances Data: 28023-90-7(Hazardous Substances Data)

Usage

General Description

4'-Chloro-3-biphenylol is a chemical compound with the molecular formula C12H9ClO. It is a chlorinated biphenyl derivative used in the production of pharmaceuticals, dyes, and other chemical products. It is a crystalline solid with a white to pale yellow color and is insoluble in water but soluble in organic solvents. 4'-Chloro-3-biphenylol has been studied for its potential biological activities and has been found to have antioxidant and antimicrobial properties. Additionally, it has been investigated for its potential use in the treatment of certain types of cancer. However, due to its potential health and environmental risks, the use and production of 4'-Chloro-3-biphenylol are closely regulated in many countries.

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Downstream Products

• 53459-39-5 4,4'-dichloro-3-biphenylol 

Relevant articles and documents

Lewis acid-promoted site-selective cyanation of phenols

An efficient Lewis acid-promoted site-selective electrophilic cyanation of 3-substituted and 3,4-disubstituted phenols has been developed. The cyanation reactions using MeSCN as the cyanating reagent proceeded efficiently to afford a wide range of 2-hydroxybenzonitriles with high efficiency and excellent regioselectivity. This protocol could provide a practical method for the synthesis and modification of biologically active molecules.

A Domino Oxidation/Arylation/Protodecarboxylation Reaction of Salicylaldehydes: Expanded Access to meta-Arylphenols

A method that allows salicylaldehydes to be efficiently transformed into meta-arylated phenol derivatives through a cascade oxidation/arylation/protodecarboxylation sequence is presented. We demonstrate that the aldehyde functional group can be used as a convenient removable directing group to control site selectivity in C-H activation. Aldehydes are easily introduced into the starting materials and the group is readily cleaved after the C-H functionalization event.

Salicylic acids as readily available starting materials for the synthesis of meta-substituted biaryls

Salicylic acids are shown to be readily available and versatile starting materials that easily undergo a tandem arylation-protodecarboxylation process under Pd-catalysis. The corresponding meta-arylphenols can subsequently be easily transformed into a var