2803-00-1Relevant articles and documents
Identification of a suspicious drug by using spectroscopic techniques: A forensic analytical chemistry project
Msimanga, Huggins Z.,Everhart, Gregory P.
, p. 161 - 166 (2012)
We identified a drug analog by using screening and confirmatory tests. Total ion chromatogram showed a major peak with a molecular ion of 190m/z, but no mass spectrum match from the NIST library. A minor peak was identified as 1-benzylpiperazine (molecular ion = 176m/z). Molecular ions of both peaks differed by 14m/z units, suggesting a -CH2 - group. Both peaks had the same base peak of 91m/z. Derivatizing the drug analog with trifluoroacetic anhydride confirmed the presence of 1-benzylpiperazine. No reaction occurred with the major peak. We proposed a benzyl-4-methylpiperazine structure, which was confirmed by NMR studies. Copyright
Synthesis of Piperazines and Thiomorpholines by Ozonolysis of Cyclic Olefins and Reductive N-Alkylation
Kawaguchi, Mamoru,Hayashi, Osamu,Kanamoto, Masahiro,Hamada, Masayuki,Yamamoto, Yukio,Oda, Jun'ichi
, p. 435 - 440 (2007/10/02)
Ozonized 1-trifluoroacetyl-3-pyrroline (2a) and 3-sulfolene (6) were reduced with sodium cyanoborohydride (1) to afford the dialdehyde, which reacted in situ with the primary amines 3ad in the presence of 1 to give the piperazines 4ad (2160 percent) and the dioxothiomorpholines 7ad (2676 percent).Reduction of 7a and 7c with diisobutylaluminum hydride yielded the thiomorpholines 8a and 8c, respectively.On the other hand, the 9-membered azacrown ethers 10 and 11 were obtained when N,N'-dibenzylethylenediamine (9) was employed.The dioxothiomorpholine derivatives 13 of amino acids were also prepared by the same treatment.
