28030-16-2

Basic information

• Product Name: Benzenepropanoic acid, 4-Methoxy-.alpha.-oxo-
• Synonyms: Benzenepropanoic acid, 4-Methoxy-.alpha.-oxo-;4-Methoxy-a-oxo-benzenepropanoic acid
• CAS NO: 28030-16-2
• Molecular Formula: C₁₀H₁₀O₄
• Molecular Weight: 194.184
• Mol File: 28030-16-2.mol
• Article Data: 20

Chemical Properties

• Melting Point: 190-192 °C(Solv: water (7732-18-5))
• Boiling Point: 342.8±25.0 °C(Predicted)
• Appearance: /
• Density: 1.256±0.06 g/cm3(Predicted)
• PKA: 2.45±0.54(Predicted)
• CAS DataBase Reference: Benzenepropanoic acid, 4-Methoxy-.alpha.-oxo-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenepropanoic acid, 4-Methoxy-.alpha.-oxo-(28030-16-2)
• EPA Substance Registry System: Benzenepropanoic acid, 4-Methoxy-.alpha.-oxo-(28030-16-2)

Safety Data

• Hazardous Substances Data: 28030-16-2(Hazardous Substances Data)

Usage

General Description

Benzenepropanoic acid, 4-Methoxy-.alpha.-oxo- is a chemical compound with the molecular formula C10H10O4. It is an organic compound with a phenylpropanoid structure, a type of natural product. This chemical has potential medicinal applications due to its reported anti-inflammatory and antioxidant properties. It is also used in the synthesis of pharmaceuticals and as a building block in organic chemistry. Additionally, it is known to have a sweet, fruity odor and is often used in the fragrance industry. Overall, Benzenepropanoic acid, 4-Methoxy-.alpha.-oxo- has various industrial and medicinal applications.

Upstream product

• 461-72-3 2,4-imidazolidinedione 
• 123-11-5 4-methoxy-benzaldehyde 
• 5349-42-8 5-(4-methoxybenzylidene)imidazolidine-2,4-dione 
• 71198-72-6 4-[(4-methoxyphenyl)methylene]-2-methyl-5(4H)-oxazolone 
• 141666-38-8 5-[1-(4-Methoxy-phenyl)-1-trimethylsilanyl-meth-(Z)-ylidene]-2-trichloromethyl-[1,3]dioxolan-4-one 
• 6331-82-4 3-(4-methoxy-phenyl)-2-thioxo-propionic acid 
• 120697-20-3 5-(4-methoxy-benzylidene)-imidazolidine-2,4-dione 
• 71198-72-6 (4Z)-4-(4-methoxybenzylidene)-2-methyl-oxazolin-5-one 
• 127220-30-8 5-[1-(4-Methoxy-phenyl)-meth-(Z)-ylidene]-2-trichloromethyl-[1,3]dioxolan-4-one 
• 73549-09-4 (Z)-2-acetamido-3-(4-methoxyphenyl)-2-propenoic acid 
• 57427-78-8 (4Z)-4-(4-methoxybenzylidene)-2-phenyl-oxazolin-5-one 
• 5429-22-1 4-(4-methoxybenzylidene)-2-phenyl-5(4H)-oxazolone 
• 58070-08-9 2-[Chloro-(4-methoxy-phenyl)-methyl]-2-hydroxy-malonic acid 
• 93515-30-1 3-(4-methoxyphenyl)-2-sulfanylpropenoic acid 

Downstream Products

• 36963-39-0 3-(4-methoxy-phenyl)-2-phenylhydrazono-propionic acid 
• 104-01-8 4-Methoxyphenylacetic acid 
• 3682-16-4 2-(hydroxyimino)-3-(4-methoxyphenyl)propanoic acid 
• 136986-56-6 ethyl anisylglyoxylate 
• 69882-69-5 methyl 3-(4-methoxyphenyl)-2-oxopropanoate 
• 858216-86-1 4-(4-methoxy-phenyl)-5-phenyl-dihydro-furan-2,3-dione 
• 6230-11-1 O-Methyltyrosine 
• 39878-65-4 (R)-β-(4-methoxyphenyl)alanine 
• 62411-81-8 3-methyl-2-[4-(methyloxy)phenyl]-2-cyclopenten-1-one 
• 2234-38-0 3,4-bis(4-methoxyphenyl)-1H-pyrrole-2,5-dicarboxylic acid 
• 56156-39-9 1,5-diphenyl-3-(p-methoxyphenyl)formazane 
• 117530-76-4 6-(4-Methoxy-benzyl)-4-phenyl-3-thioxo-3,4-dihydro-2H-[1,2,4]triazin-5-one 
• 98515-75-4 4-Amino-3-mercapto-6-(4-methoxy-benzyl)-4H-[1,2,4]triazin-5-one 
• 112517-73-4 3-Mercapto-6-(4-methoxy-benzyl)-2H-[1,2,4]triazin-5-one 

Relevant articles and documents

Chemoenzymatic synthesis of L-3,4-dimethoxyphenyl-alanine and its analogues using aspartate aminotransferase as a key catalyst

In this study, a chemoenzymatic synthesis method for the production of L-3,4-dimethoxyphenyl-alanine and its analogues from phenylpyruvate derivatives was developed. The aspartate aminotransferase from Escherichia coli was engineered by error prone PCR and the improved variants were identified. When 3, 4-dimethoxy phenylpyruvate was added by fed-batch on a preparative scale, L-3,4-dimethoxyphenyl-alanine was formed in 95.4% conversion and > 99% ee with the best aspartate aminotransferase variant as the catalyst. This study provided an efficient method for the production of methoxy substituted phenylalanines using the engineered aspartate aminotransferase.

Synthesis and antiproliferative activity of marine bromotyrosine purpurealidin I and its derivatives

The first total synthesis of the marine bromotyrosine purpurealidin I (1) using trifluoroacetoxy protection group and its dimethylated analog (29) is reported along with 16 simplified bromotyrosine derivatives lacking the tyramine moiety. Their cytotoxici