28033-32-1

Basic information

• Product Name: 4-(2-METHOXYPHENOXY)PIPERIDINE
• Synonyms: 4-(2-Methoxyphenoxy)piperidine;4-(2-methoxyphenoxy)piperidine(SALTDATA: FREE);Piperidine,4-(2-Methoxyphenoxy-;Piperidine,4-(O-Methoxyphenoxy- (8Ci
• CAS NO: 28033-32-1
• Molecular Formula: C₁₂H₁₇NO₂
• Molecular Weight: 207.27
• Mol File: 28033-32-1.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 306.7°C at 760 mmHg
• Flash Point: 124.7°C
• Appearance: /
• Density: 1.057g/cm³
• Vapor Pressure: 0.000758mmHg at 25°C
• Refractive Index: 1.517
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 4-(2-METHOXYPHENOXY)PIPERIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2-METHOXYPHENOXY)PIPERIDINE(28033-32-1)
• EPA Substance Registry System: 4-(2-METHOXYPHENOXY)PIPERIDINE(28033-32-1)

Safety Data

• Hazardous Substances Data: 28033-32-1(Hazardous Substances Data)

Usage

General Description

4-(2-Methoxyphenoxy)piperidine is a chemical compound with the molecular formula C13H19NO2. It is a piperidine derivative with a methoxyphenoxy group attached to the piperidine ring. 4-(2-METHOXYPHENOXY)PIPERIDINE is used in medicinal chemistry and pharmaceutical research as a building block for the synthesis of various heterocyclic compounds with potential biological activity. Its unique structural features make it a valuable precursor for the development of new drug candidates and potential pharmacological agents. The compound's properties and potential applications make it an important target for further chemical and pharmacological studies.

InChI:InChI=1/C12H17NO2/c1-14-11-4-2-3-5-12(11)15-10-6-8-13-9-7-10/h2-5,10,13H,6-9H2,1H3

Upstream product

• 944808-11-1 tert-butyl 4-(2-methoxyphenoxy)piperidine-1-carboxylate 
• 109384-19-2 t-butyl 4-hydroxy piperidine-1-carboxylate 
• 90-05-1 2-methoxy-phenol 
• 253603-59-7 1-benzyl-4-(2-methoxyphenoxy)piperidine 

Relevant articles and documents

DUAL NAV1.2/5HT2A INHIBITORS FOR TREATING CNS DISORDERS

Compounds of formula I: I are disclosed, as are pharmaceutical compositions containing such compounds. Methods of treating neurological or psychiatric disorders in a patient in need are also disclosed. Such disorders include depression, bipolar disorder, pain, schizophrenia, obsessive compulsive disorder, addiction, social disorder, attention deficit hyperactivity disorder, an anxiety disorder, autism, a cognitive impairment, or a neuropsychiatric symptom such as apathy, depression, anxiety, psychosis, aggression, agitation, impulse control disorders, and sleep disorders in neurological disorders such as Alzheimer's and Parkinson's diseases.

2-(Aryloxy)ethylamine derivatives: Ring opened congeners of long chain 1-arylpiperazines with high 5-HT(1A) receptor affinity and selectivity versus D2 and α1 receptors

1-Aryl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1- yl)propyl]piperazine derivatives, previously reported as 5-HT(1A)/D2 ligands, were modified by opening the piperazine ring. Twenty-two ring opened congeners were prepared and their affinity for serotonin 5-HT(1A), dopamine D2, and α1-adrenergic receptors was measured in vitro. Among the herein reported compounds, the 2(aryloxy)ethylamine derivatives 38-40, 43 and 44 displayed 5-HT(1A) receptor affinity in the nanomolar range. In particular, compound 44 was found to be a potent and selective 5-HT(1A) ligand (K(i)= 0.71 nM), completely devoid of D2 and α1 receptor binding affinity. Our data indicate that removal of the ethylene chain of the piperazine ring, together with an isosteric substitution, can lead to ligand with high 5- HT(1A) receptor affinity and selectivity. Furthermore, compounds 40 and 44 were submitted to the [35S]GTPγS binding assay for a preliminary evaluation of their intrinsic activity on the 5-HT(1A) receptor.