28036-11-5Relevant articles and documents
Visible-Light photo-Arbuzov reaction of aryl bromides and trialkyl phosphites yielding aryl phosphonates
Shaikh, Rizwan S.,Düsel, Simon J.S.,K?nig, Burkhard
, p. 8410 - 8414 (2018/05/23)
Aryl phosphonates are functional groups frequently found in pharmaceutical and crop protection agents. For their synthesis via C?P bond formation typically transition-metal-catalyzed reactions are used. We report a visible-light photo-Arbuzov reaction as an efficient, mild, and metal-free alternative. Rhodamine 6G (Rh.6G) is used as the photocatalyst, generating aryl radicals under blue light. Coupling of the radicals with a wide range of trivalent phosphites gives aryl phosphonates in good to very good isolated yields. The mild reaction conditions allow the introduction of a phosphonate group into complex and sensitive pharmaceutically active molecules such as benzodiazepams and nicergoline by the activation of a carbon?halogen bond.
THE PREPARATION AND DIELS-ALDER REACTIVITY OF ETHYL (DIETHOXYPHOSPHINYL)PROPYNOATE
Hall, Roger G.,Trippett, Stuart
, p. 2603 - 2604 (2007/10/02)
Ethyl (diethoxyphospinyl)propynoate has been prepared.It is a highly reactive and regiospecific dienophile.
