280579-73-9

Basic information

• Product Name: 4-Anilino-5-[(5-methylisoxazol-3-yl)oxymethyl]-2-{4-[2-hydroxy-3-(N,N-dimethylamino)propoxy]anilino}pyrimidine
• Synonyms: 4-Anilino-5-[(5-methylisoxazol-3-yl)oxymethyl]-2-{4-[2-hydroxy-3-(N,N-dimethylamino)propoxy]anilino}pyrimidine
• CAS NO: 280579-73-9
• Molecular Weight: 490.562
• Mol File: 280579-73-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-Anilino-5-[(5-methylisoxazol-3-yl)oxymethyl]-2-{4-[2-hydroxy-3-(N,N-dimethylamino)propoxy]anilino}pyrimidine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Anilino-5-[(5-methylisoxazol-3-yl)oxymethyl]-2-{4-[2-hydroxy-3-(N,N-dimethylamino)propoxy]anilino}pyrimidine(280579-73-9)
• EPA Substance Registry System: 4-Anilino-5-[(5-methylisoxazol-3-yl)oxymethyl]-2-{4-[2-hydroxy-3-(N,N-dimethylamino)propoxy]anilino}pyrimidine(280579-73-9)

Safety Data

• Hazardous Substances Data: 280579-73-9(Hazardous Substances Data)

Upstream product

• 10004-44-1 hymexazole 
• 280579-66-0 4-Anilino-5-(ethoxymethyl)-2-{4-[2-hydroxy-3-(N,N-dimethylamino)propoxy]anilino }pyrimidine 

Relevant articles and documents

2,4-diamino pyrimidine compounds having anti-cell proliferative activity

A pyrimidine derivative of formula (I): wherein: R1is an optional substituent as defined within; Rxis selected from halo, hydroxy, nitro, amino, cyano, mercapto, carboxy, sulphamoyl, formamido, ureido or carbamoyl or a group of formula (Ib): A—B—C— as defined within; Q1and Q2are independently selected from aryl, a 5- or 6-membered monocyclic moiety; and a 9- or 10-membered bicyclic heterocyclic moiety; and one or both of Q1and Q2bears on any available carbon atom one substituent of formula (Ia) as defined within; and Q1and Q2are optionally further substituted; or a pharmaceutically acceptable salt or in vivo hydrolysable ester thereof; are useful as anti-cancer agents; and processes for their manufacture and pharmaceutical compositions containing them are described.