28092-52-6Relevant articles and documents
Practical Synthesis of (+)-Biotin Key Intermediate by Calcium Borohydride Reduction and Temperature-Dependent Purity Upgrade during Crystallization
Seki, Masahiko,Takahashi, Yusuke
, p. 1950 - 1959 (2021/08/03)
An expedient synthesis of a key intermediate for (+)-biotin has been accomplished through high-yielding reduction of chiral imide with calcium borohydride and efficient isolation of the desired isomer by crystallization at a specific temperature where only undesired isomer was converted to soluble anhydrate while the desired isomer kept unchanged as a less soluble monohydrate.
METHOD FOR PRODUCING THIOLACTONE COMPOUND
-
Paragraph 0101-0103, (2021/02/26)
To provide a production method for obtaining a high-purity thiolactone compound at good yields.SOLUTION: A method for producing a thiolactone compound includes crystallizing and extracting a thiolactone compound of the following formula in an alcohol solvent with a boiling point of 85°C or higher, where R1 and R2 each denote H or a ureine protection group such as a benzyl group.SELECTED DRAWING: None
Amide derivatives, the amide derivative and (by machine translation)
-
Paragraph 0075-0078, (2020/09/24)
[Problem] amide derivative useful as an intermediate for synthesis of biotin, and method for producing an amide derivative. [Solution] the corresponding alcohol derivative, mesyl agent, such as agent manufactured by reacting sulfonyl, an amide derivative represented by the formula. (In the formula R1 And R2 The, same or different, substituted or unsubstituted benzyl group, R3 Is, substituted or unsubstituted phenyl group, X is, thiol groups, [meshirokishi[meshirokishi] group, a trifluoromethanesulfonyloxy group, p - [toshirokishi[toshirokishi] groups, such as halogen groups are selected from the group. )[Drawing] no (by machine translation)