28103-25-5

Basic information

• Product Name: 3-nitroso-2-phenylimidazo[1,2-a]pyrimidine
• Synonyms: 3-Nitroso-2-phenylimidazo(1,2-a)pyrimidine; 3-Nitroso-2-phenylimidazo[1,2-a]pyrimidine
• CAS NO: 28103-25-5
• Molecular Formula: C₁₂H₈N₄O
• Molecular Weight: 224.2181
• Mol File: 28103-25-5.mol
• Article Data: 4

Chemical Properties

• Density: 1.37g/cm³
• Refractive Index: 1.719
• CAS DataBase Reference: 3-nitroso-2-phenylimidazo[1,2-a]pyrimidine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-nitroso-2-phenylimidazo[1,2-a]pyrimidine(28103-25-5)
• EPA Substance Registry System: 3-nitroso-2-phenylimidazo[1,2-a]pyrimidine(28103-25-5)

Safety Data

• Hazardous Substances Data: 28103-25-5(Hazardous Substances Data)

Upstream product

• 70-11-1 α-bromoacetophenone 
• 4937-87-5 N-hydroxy-2-oxo-2-phenylethanimidoyl chloride 
• 15764-47-3 2-phenylimidazo(1,2-a)pyrimidine 

Downstream Products

• 42837-61-6 5-amino-3-benzoyl-1,2,4-oxadiazole 
• 89185-42-2 N-(2-pyrimidyl)-benzimidoyl cyanide 
• 89185-48-8 2-phenylimidazo[1,2-a]pyrimidin-3-ylamine 

Relevant articles and documents

Synthesis and antibacterial activity of some imidazo[1,2-a[pyrimidine derivatives

A series of 75 imidazo[1,2-a]pyrimidine derivatives were synthesized. The 'in vitro' antibacterial activity of these compounds and their corresponding α-bromoketones against a variety of gram (+), gram (-) bacteria and Mycobacterium species is reported. Some of the prepared derivatives exhibited potent antimicrobial activity.

Convenient Synthesis of Fused Heterocycles from α-Ketohydroximoyl Chlorides and Heterocyclic Amines

Nitroso derivatives of imidazopyridine (11,13,14), imidazopyrimidine (15), imidazopyrazine (16), imidazopyrazole (17), and imidazo-1,2,4-triazole (19) were obtained in good yields from α-ketohydroximoyl chlorides 3 and 2-aminopyrazines (4-6), 2-aminopyrimidine (7), 2-aminopyrazine (8), 5-amino-3-phenylpyrazole (9), and 3-amino-2H-1,2,4-triazole (10), respectively.Under different conditions, the reaction of 3 with 3-amino-2H-1,2,4-triazole (10) and 2-aminopyrazine (8) afforded the noncyclized substitution products 18 and 22, respectively.The structures of the products were assigned and confirmed on the basis of their elemental analyses, spectral data, and alternate synthesis wherever possible.