281191-03-5Relevant articles and documents
Synthesis of bioactive natural products by asymmetric syn-and anti-aldol reactions
Ghosh, Arun K.,Dawson, Zachary L.
body text, p. 2992 - 3002 (2010/04/02)
The use of several variants of the asymmetric aldol reaction as key steps in the syntheses of bioactive target molecules is described. Georg Thieme Verlag Stuttgart.
A convergent synthesis of (+)-cryptophycin B, a potent antitumor macrolide from Nostoc sp. cyanobacteria.
Ghosh,Bischoff
, p. 1573 - 1575 (2007/10/03)
[structure--see text] An efficient and highly stereoselective synthesis of cryptophycin B (2), a potent cytotoxic agent, is described. The ester-derived titanium-enolate-mediated syn-aldol reaction was employed to generate the stereocenters C(5) and C(6). The route is convergent and provides a convenient access to the synthesis of structural variants of cryptophycin B as well as members of its family.