281234-90-0

Basic information

• Product Name: 4-(4-Amino-piperidin-1-yl)-benzonitrile
• CAS NO: 281234-90-0
• Molecular Formula: C12H15N3
• Molecular Weight: 201.271
• Mol File: 281234-90-0.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 4-(4-Amino-piperidin-1-yl)-benzonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-Amino-piperidin-1-yl)-benzonitrile(281234-90-0)
• EPA Substance Registry System: 4-(4-Amino-piperidin-1-yl)-benzonitrile(281234-90-0)

Safety Data

• Hazardous Substances Data: 281234-90-0(Hazardous Substances Data)

Upstream product

• 623-00-7 4-bromobenzenecarbonitrile 
• 35621-01-3 4-aminopiperidine dihydrochloride 
• 344566-78-5 tert-butyl (1-(4-cyanophenyl)piperidin-4-yl)carbamate 
• 1194-02-1 4-fluorobenzonitrile 
• 73874-95-0 (piperidin-4-yl)carbamic acid tert-butyl ester 
• 1452394-20-5 4-(4-azidopiperidin-1-yl)benzonitrile 
• 180695-80-1 tert-butyl 4-azidopiperidine-1-carboxylate 

Downstream Products

• 1291057-90-3 4-[4-(3-benzo[b]thiophen-3-yl-3-hydroxypropylamino)piperidin-1-yl]benzonitrile 
• 1291057-83-4 4-[4-(3-benzo[b]thiophen-3-yl-3-oxopropylamino)piperidin-1-yl]benzonitrile 
• 247035-04-7 4-[4-{(tert-butoxycarbonyl)amino}piperidin-1-yl]benzoic acid 
• 281234-89-7 4-(4-Amino-piperidin-1-yl)-benzoic acid 

Relevant articles and documents

Disubstituted 1-aryl-4-aminopiperidine library synthesis using computational drug design and high-throughput batch and flow technologies

A platform that incorporates computational library design, parallel solution-phase synthesis, continuous flow hydrogenation, and automated high throughput purification and reformatting technologies was applied to the production of a 120-member library of 1-aryl-4-aminopiperidine analogues for drug discovery screening. The application described herein demonstrates the advantages of computational library design coupled with a flexible, modular approach to library synthesis. The enabling technologies described can be readily adopted by the traditional medicinal chemist without extensive training and lengthy process development times.

Non-nucleoside reverse transcriptase inhibitors

The present invention provides for compounds useful for treating an HIV infection, or preventing an HIV infection, or treating AIDS or ARC. The compounds of the invention are of formula I wherein R1, R2, R3, R4, R5a, R5b, R6a, R6b and X are as herein defined. Also disclosed in the present invention are methods of treating an HIV infection with compounds defined herein and pharmaceutical compositions containing said compounds.

Remarkably selective palladium-catalyzed amination process: Rapid assembly of multiamino based structures

Palladium-catalyzed selective amination by a primary amine in the presence of a secondary amine provided up to >99:1 selectivity with high yields.