28128-25-8 Usage
Description
6-Amino-2-bromopurine is an organic compound with the molecular formula C5H4BrN5. It is a derivative of purine, a key component of nucleic acids and energy metabolism. 6-Amino-2-bromopurine is characterized by the presence of a bromine atom at the 2nd position and an amino group at the 6th position of the purine ring.
Uses
Used in Radioprotective Applications:
6-Amino-2-bromopurine is used as a radioprotective agent for increasing the radiosensitivity of bone marrow hemopoietic stem cells in mice. When injected before exposure to irradiation, it helps to enhance the cells' ability to withstand the damaging effects of radiation, potentially improving the survival rate and overall health of the animals subjected to such treatments.
Note: The provided materials mention 8-Bromoadenine, which is a different compound from 6-Amino-2-bromopurine. However, since the task is to organize the description and uses of 6-Amino-2-bromopurine, the information about 8-Bromoadenine is not directly applicable. If there are any specific uses or applications for 6-Amino-2-bromopurine in different industries, they should be listed separately following the format provided in the example.
Check Digit Verification of cas no
The CAS Registry Mumber 28128-25-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,8,1,2 and 8 respectively; the second part has 2 digits, 2 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 28128-25:
(7*2)+(6*8)+(5*1)+(4*2)+(3*8)+(2*2)+(1*5)=108
108 % 10 = 8
So 28128-25-8 is a valid CAS Registry Number.
InChI:InChI=1/C5H4BrN5/c6-5-10-3(7)2-4(11-5)9-1-8-2/h1H,(H3,7,8,9,10,11)
28128-25-8Relevant articles and documents
Isolation, synthesis, and characterization of impurities and degradants from the clofarabine process
Anderson, Bruce G.,Bauta, William E.,Cantrell Jr., William R.,Engles, Tracy,Lovett, Dennis P.
, p. 1229 - 1237 (2013/01/03)
The identification of clofarabine process impurities and their subsequent isolation, synthesis, and characterization is described. Two isomeric process impurities resulting from N6-attachment of a fluoroarabinose to clofarabine were found. Clofarabine's base degradation products, which were different from the process impurities, were also synthesized and characterized. These compounds resulted from modifications to the sugar moiety, the purine ring, or both. A mechanistic rationale for the formation of the various process impurities and degradation products is provided.
Improved synthesis and antitumor activity of 2-bromo-2'- deoxyadenosine
Huang,Avery,Blakley,Secrist III,Montgomery
, p. 800 - 802 (2007/10/02)
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