28147-35-5

Basic information

• Product Name: 9H-fluoren-4-ol
• Synonyms: 9H-fluoren-4-ol
• CAS NO: 28147-35-5
• Molecular Formula: C₁₃H₁₀O
• Molecular Weight: 182.2179
• Mol File: 28147-35-5.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 372.1°Cat760mmHg
• Flash Point: 182°C
• Appearance: /
• Density: 1.241g/cm³
• Vapor Pressure: 4.61E-06mmHg at 25°C
• Refractive Index: 1.683
• CAS DataBase Reference: 9H-fluoren-4-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 9H-fluoren-4-ol(28147-35-5)
• EPA Substance Registry System: 9H-fluoren-4-ol(28147-35-5)

Safety Data

• Hazardous Substances Data: 28147-35-5(Hazardous Substances Data)

Usage

General Description

9H-Fluoren-4-ol is a chemical compound that belongs to the class of fluorene derivatives. It is also known as 4-Fluorenol and is a white to off-white solid with a slightly sweet, floral odor. 9H-Fluoren-4-ol is mainly used as a pharmaceutical intermediate and in the manufacturing of pharmaceuticals, dyes, and fluorescent chemical compounds. It is also used in the synthesis of novel organic materials, and as a reagent in organic reactions. The compound has been the subject of research for its potential anti-inflammatory and anticancer properties, and it is important to handle and store it with proper precautions due to its potential hazards if mishandled.

InChI:InChI=1/C13H10O/c14-12-7-3-5-10-8-9-4-1-2-6-11(9)13(10)12/h1-7,14H,8H2

Upstream product

• 86-73-7 9H-fluorene 

Relevant articles and documents

Insight into the chemoselective aromatic: Vs. side-chain hydroxylation of alkylaromatics with H2O2catalyzed by a non-heme imine-based iron complex

The oxidation of a series of alkylaromatic compounds with H2O2 catalyzed by an imine-based non-heme iron complex prepared in situ by reaction of 2-picolylaldehyde, 2-picolylamine, and Fe(OTf)2 in a 2?:?2?:?1 ratio leads to a marked chemoselectivity for aromatic ring hydroxylation over side-chain oxidation. This selectivity is herein investigated in detail. Side-chain/ring oxygenated product ratio was found to increase upon decreasing the bond dissociation energy (BDE) of the benzylic C-H bond in line with expectation. Evidence for competitive reactions leading either to aromatic hydroxylation via electrophilic aromatic substitution or side-chain oxidation via benzylic hydrogen atom abstraction, promoted by a metal-based oxidant, has been provided by kinetic isotope effect analysis. This journal is

Oxygenation reactions of various tricyclic fused aromatic compounds using Escherichia coli and Streptomyces lividans transformants carrying several arene dioxygenase genes.

Bioconversion (biotransformation) experiments on arenes (aromatic compounds), including various tricyclic fused aromatic compounds such as fluorene, dibenzofuran, dibenzothiophene, carbazole, acridene, and phenanthridine, were done using the cells of Escherichia coli transformants expressing several arene dioxygenase genes. E. coli carrying the phenanthrene dioxygenase (phdABCD) genes derived from the marine bacterium Nocardioides sp. strain KP7 converted all of these tricyclic aromatic compounds, while E. coli carrying the Pseudomonas putida F1 toluene dioxygenase (todC1C2BA) genes or the P. pseudoalcaligenes KF707 biphenyl dioxygenase (bphA1A2A3A4) genes was not able to convert these substrates. Surprisingly, E. coli carrying hybrid dioxygenase (todC1::bphA2A3A4) genes with a subunit substitution between the toluene and biphenyl dioxygenases was able to convert fluorene, dibenzofuran, and dibenzothiophene. The cells of a Streptomyces lividans transformant carrying the phenanthrene dioxygenase genes were also evaluated for bioconversion of various tricyclic fused aromatic compounds. The ability of this actinomycete in their conversion was similar to that of E. coli carrying the corresponding genes. Products converted from the aromatic compounds with these recombinant bacterial cells were purified by column chromatography on silica gel, and identified by their MS and 1H and 13C NMR analyses. Several products, e.g., 4-hydroxyfluorene converted from fluorene, and cis-1,2-dihydroxy-1,2-dihydrophenanthridine, cis-9,10-dihydroxy-9,10-dihydrophenanthridine, and 10-hydroxyphenanthridine, which were converted from phenanthridine, were novel compounds.