28162-88-1Relevant articles and documents
Fluorescent-labeled excision type nucleotide, synthetic method and application of fluorescent-labeled excision type nucleotide in DNA sequencing
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, (2018/11/27)
The invention relates to a fluorescent-labeled excision type nucleotide. The fluorescent-labeled excision type nucleotide is characterized by comprising a structure as shown in the general formula (I), wherein in the general formula (I), Fluorescent repre
Design, synthesis, and pharmacological evaluation of glutamate carboxypeptidase II (GCPII) inhibitors based on thioalkylbenzoic acid scaffolds
Stoermer, Doris,Vitharana, Dilrukshi,Hin, Niyada,Delahanty, Greg,Duvall, Bridget,Ferraris, Dana V.,Grella, Brian S.,Hoover, Randall,Rojas, Camilo,Shanholtz, Megan K.,Smith, Kyle P.,Stathis, Marigo,Wu, Ying,Wozniak, Krystyna M.,Slusher, Barbara S.,Tsukamoto, Takashi
experimental part, p. 5922 - 5932 (2012/07/30)
A series of thiol-based glutamate carboxypeptidase II (GCPII) inhibitors have been synthesized with either a 3-(mercaptomethyl)benzoic acid or 2-(2-mercaptoethyl)benzoic acid scaffold. Potent inhibitors were identified from each of the two scaffolds with IC50 values in the single-digit nanomolar range, including 2-(3-carboxybenzyloxy)-5-(mercaptomethyl)benzoic acid 27c and 3-(2-mercaptoethyl)biphenyl-2,3'-dicarboxylicacid 35c. Compound 35c was found to be metabolically stable and selective over a number of targets related to glutamate-mediated neurotransmission. Furthermore, compound 35c was found to be orally available in rats and exhibited efficacy in an animal model of neuropathic pain following oral administration.
COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT
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Page/Page column 61, (2012/02/01)
Compounds having activity as phosphate transport inhibitors, more specifically, inhibitors of intestinal apical membrane Na/phosphate co-transport, are disclosed. The compounds have the following structure (I): including stereoisomers, pharmaceutically ac
