28167-49-9 Usage
Description
N-Methyl-methamidophos, also known as an organophosphate insecticide and acaricide, is a highly toxic chemical compound widely used in agriculture to control various pests. It functions by inhibiting the enzyme acetylcholinesterase, which results in overstimulation of the nervous system and ultimately leads to paralysis and death in insects and other target organisms. However, it is also highly toxic to humans and other non-target species, posing potential acute and chronic health effects such as nausea, vomiting, dizziness, respiratory distress, and neurological damage. Due to its high toxicity and potential for environmental contamination, the use of N-methyl-methamidophos is strictly regulated in many countries.
Uses
Used in Agricultural Industry:
N-Methyl-methamidophos is used as an insecticide and acaricide for controlling a variety of pests in agricultural settings. It is effective in managing insect populations that can damage crops and reduce agricultural productivity.
However, due to its high toxicity and potential for environmental contamination, it is essential to follow strict regulations and guidelines for its use in agriculture to minimize risks to human health and the environment.
Check Digit Verification of cas no
The CAS Registry Mumber 28167-49-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,8,1,6 and 7 respectively; the second part has 2 digits, 4 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 28167-49:
(7*2)+(6*8)+(5*1)+(4*6)+(3*7)+(2*4)+(1*9)=129
129 % 10 = 9
So 28167-49-9 is a valid CAS Registry Number.
28167-49-9Relevant articles and documents
Synthesis, spectroscopic characterization and structure-activity relationship of some phosphoramidothioate pesticides
Ghadimi,Asad-Samani,Ebrahimi-Valmoozi
experimental part, p. 717 - 726 (2012/07/14)
In this work, some phosphoramidothioates (PATs) with the general formula of (CH3O)2P(S)X and (CH3O)(CH3S)P(O)X, where, X = NH2 (1 & 6), NH(CH3) (2 & 7), N(CH3)2 (3 & 8), N(Et)2 (4 & 9), (CH3CH2O)2P(S)NH(CH3) (5) and (CH3CH2O)(CH3CH2S)P(O)NH(CH 3) (10), were synthesized and characterized by 31P, 31P{1H}, 13C and 1H NMR spectroscopy. The ability of the compounds to inhibit AChE was predicted by PASS software (version 1.193). They were also experimentally evaluated by a modified Ellman's assay. The structure-activity relationship (SAR) between IC50 and some physico-chemical properties such as lipophilicity (logP), electronic and steric effects of the compounds was studied. The logP values were experimentally determined by the shake-flask (gas chromatography) method. Inhibitory potency for the compounds 1-10 was 1 (3.38 mM) > 2 (3.97 mM) > 3 (4.75 mM) > 4 (6.00 mM) > 5 (5.51 mM) > 6 (0.07 mM) > 7 (0.23 mM) > 8 (0.39 mM) > and 9 (0.55 mM) > 10 (0.51 mM), respectively. IC50 and logP parameters of the P=O moiety were more than the P=S moiety in PAT analogues.
