282734-63-8

Basic information

• Product Name: 2-iodo-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine
• Synonyms: 2-iodo-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine;1H-Pyrrolo[2,3-b]pyridine, 2-iodo-1-(phenylsulfonyl)-;2-Iodo-1-(phenylsulfonyl)-7-azaindole;1-Benzenesulfonyl-2-iodo-7-azaindole;1-Benzenesulfonyl-2-iodo-1H-pyrrolo[2,3-b]pyridine;2-Iodo-1-(phenylsulfonyl)...;2-Iodo-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b];1-(Benzenesulfonyl)-2-iodopyrrolo[2,3-b]pyridine
• CAS NO: 282734-63-8
• Molecular Formula: C₁₃H₉IN₂O₂S
• Molecular Weight: 384.19
• Product Categories: Heterocycle-Pyridine series
• Mol File: 282734-63-8.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 529.861 °C at 760 mmHg
• Flash Point: 274.25 °C
• Appearance: /
• Density: 1.831 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.736
• PKA: 0.21±0.30(Predicted)
• CAS DataBase Reference: 2-iodo-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-iodo-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine(282734-63-8)
• EPA Substance Registry System: 2-iodo-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine(282734-63-8)

Safety Data

• Hazardous Substances Data: 282734-63-8(Hazardous Substances Data)

Usage

General Description

2-iodo-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine is a chemical compound with the molecular formula C12H8IN2O2S. It is a pyrrolopyridine derivative that contains a sulfonyl group attached to a phenyl ring and an iodine atom attached to the pyrrole ring. 2-iodo-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine has potential applications in medicinal chemistry and drug discovery due to its unique structure and potential biological activities. Its synthesis and properties make it a valuable building block for the development of new pharmaceuticals and agrochemicals. Additionally, its chemical structure makes it a potential candidate for further modifications and structure-activity relationship studies in drug development and discovery.

InChI:InChI=1/C13H9IN2O2S/c14-12-9-10-5-4-8-15-13(10)16(12)19(17,18)11-6-2-1-3-7-11/h1-9H

Upstream product

• 271-63-6 7-Azaindole 
• 98-09-9 benzenesulfonyl chloride 
• 143141-23-5 1-benzenesulfonyl-1H-pyrrolo[2,3-b]pyridine 

Downstream Products

• 1485294-48-1 2-[1-(3-azidomethylbenzyl)-1H-[1,2,3]triazol-4-yl]-1H-pyrrolo[2,3-b]pyridine 
• 1485294-38-9 C₂₄H₂₆N₈ 
• 1227270-32-7 2-iodo-1H-pyrrolo[2,3-b]pyridine 
• 282734-73-0 methyl 9-phenylsulfonyl-5,6,7,8-tetrahydro-9H-pyrido[2,3-b]indole-5-carboxylate 
• 282734-70-7 methyl (E)-3-[(1-phenylsulfonyl)-1H-pyrrolo [2,3-b]-pyridin-2-yl]propenoate 
• 282734-64-9 1-phenylsulfonyl-2-vinyl-1H-pyrrolo[2,3-b]pyridine 

Relevant articles and documents

ESTROGEN RECEPTOR ANTAGONIST

Provided is an indole compound. In particular, disclosed are a compound represented by formula (II) or an isomer or pharmaceutically acceptable salt thereof and a use of the same as an estrogen receptor antagonist in preparing a drug for treating estrogen receptor-positive breast cancer.

Synthesis, biological evaluation and molecular modeling of a novel series of 7-azaindole based tri-heterocyclic compounds as potent CDK2/Cyclin E inhibitors

From four molecules, inspired by the structural features of fascaplysin, with an interesting potential to inhibit cyclin-dependent kinases (CDKs), we designed a new series of tri-heterocyclic derivatives based on 1H-pyrrolo[2,3-b]pyridine (7-azaindole) an

A convenient iodination of indoles and derivatives

We report a direct iodination of indole and derivative compounds with iodine monochloride (ICl) in the presence of Celite. This procedure has now been extended to the iodination of substituted indoles, azaindoles and pyrroles. The scope of this procedure