28281-58-5

Basic information

• Product Name: 7-Methoxyphthalide
• Synonyms: 7-Methoxyphthalide;1(3H)-Isobenzofuranone,7-methoxy-(9CI);7-METHOXYISOBENZOFURAN-1(3H)-ONE
• CAS NO: 28281-58-5
• Molecular Formula: C₉H₈O₃
• Molecular Weight: 164.15802
• Product Categories: PHENYL
• Mol File: 28281-58-5.mol
• Article Data: 27

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 7-Methoxyphthalide(CAS DataBase Reference)
• NIST Chemistry Reference: 7-Methoxyphthalide(28281-58-5)
• EPA Substance Registry System: 7-Methoxyphthalide(28281-58-5)

Safety Data

• Hazardous Substances Data: 28281-58-5(Hazardous Substances Data)

Upstream product

• 186581-53-3 diazomethane 
• 124-38-9 carbon dioxide 
• 52520-37-3 (3-Methoxybenzyl alcohol)chromium Tricarbonyl 
• 6971-51-3 3-methoxybenzyl alcohol 
• 108444-20-8 3-hydroxy-7-methoxy-2-phenyl-2,3-dihydro-1H-isoindol-1-one 
• 15184-99-3 N,N-dimethyl-3-methoxybenzylamine 
• 2944-49-2 2,3-dimethylanisole 
• 71887-28-0 methyl 2-(bromomethyl)-3-methoxybenzoate 
• 130662-48-5 4-bromo-7-methoxyisobenzofuran-1(3H)-one 
• 6161-65-5 2-methoxy-6-methyl-benzoic acid 
• 79383-44-1 methyl 2-methyl-6-methoxybenzoate 
• 133379-09-6 methyl 5-bromo-2-methoxy-6-methylbenzoate 
• 133379-08-5 methyl 3-bromo-2-(bromomethyl)-6-methoxybenzoate 
• 90047-52-2 3-methoxy-o-xylene-α,α'-diol 

Downstream Products

• 887645-09-2 7-methoxy-3-[2-amino-5-(2-dimethyaminoethoxy)benzylidene]phthalide 
• 887645-04-7 7-methoxy-3-[2-nitro-5-(2-dimethyaminoethoxy)benzylidene]phthalide 
• 887645-14-9 5-[2-(dimethylamino)ethoxy]-2-(2-carboxy-3-methoxyphenyl)indole 
• 1282618-75-0 7-(benzyloxy)-1-methoxy-1,3-dihydroisobenzofuran 
• 1313222-58-0 C₁₅H₁₄O₃ 
• 111317-39-6 7-(benzyloxy)isobenzofuran-1(3H)-one 
• 80241-82-3 methyl 2-formyl-6-methoxybenzoate 
• 90047-52-2 3-methoxy-o-xylene-α,α'-diol 
• 53015-08-0 2-formyl-6-methoxy-benzoic acid 
• 11048-15-0 kalafungin 

Relevant articles and documents

Combining Photodeprotection and Ligation into a Dual-Color Gated Reaction System

We report a photochemical reaction system which requires activation by two colors of light. Specifically, a dual wavelength gated system is established by fusing the visible light mediated deprotection of a dithioacetal with the UV light activated Diels–A

Assessment of the regioselectivity in the condensation reaction of unsymmetrical o-phthaldialdehydes with alanine

One approach for the synthesis of isoindolinones, a privileged bioactive heterocyclic core structure, involves a condensation reaction of o-phthaldialdehydes with a suitable nitrogen-containing nucleophile. This fascinating reaction is revisited here in the context of the use of o-phthaldialdehydes that contain additional substituents in the aromatic ring leading to a detailed analysis of the regioselectivity of the reaction. Eleven monosubstituted o-phthaldialdehydes were synthesised and reacted with alanine. The regioselectivity observed across the eleven substrates led to the design of a disubstituted substrate that reacted with very high control. A gram-scale reaction followed by esterification gave one major regioisomer in high yield. In addition, the regioselectivity observed on reaction of two novel monodeuterated substrates led to an increased mechanistic understanding.

Stereoselective total synthesis of (+)-varitriol

Stereoselective total synthesis of (+)-varitriol, an antitumor natural product, was accomplished by two versatile strategies starting from the commercially available d-(-)-ribose and ethyl (S)-lactate. The key steps involved in the synthesis of the target molecule are epoxidation, cyclization, dihydroxylation and Diels-Alder reaction.