28286-05-7Relevant articles and documents
1,3-Dioxolanes of N-Substituted 4-Piperidones as Substrates for Dehydrogenations
Mo?hrle,Jeandre?e
, p. 72 - 78 (2007/10/03)
The applicability of ketals was examined for masking the carbonyl group in N-tertiary 4-piperidones during the dehydrogenation using mercury-edta. Various 1,3-dioxolanes showed a different behaviour in dependence on the N-substituent. With simple aliphatic moieties mainly dehydrogenated but hydrolyzed products were received. These enaminones were also available from the dehydrogenations of the corresponding 4-piperidones. Similar applied to para-acyl-aromatic substituted derivatives but with less yields. Aromatic substituents bearing a neighbour group on ortho-position with participation gave rise to different oxidation products partially with preservation of the ketal structure.
Neurotropic and psychotropic agents. LXVII. 1 [4,4 bis(4 fluorophenyl)butyl] 4 hydroxy 4 (3 trifluoromethyl 4 chlorophenyl)piperidine and related compounds: new synthetic approaches
Sindelar,Rajsner,Cervena,et al.
, p. 3879 - 3901 (2007/10/04)
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