28315-93-7Relevant articles and documents
A metal-free method for the facile synthesis of indanonesviathe intramolecular hydroacylation of 2-vinylbenzaldehyde
He, Guoxue,Ma, Jinyu,Zhou, Jianhui,Li, Chunpu,Liu, Hong,Zhou, Yu
supporting information, p. 1036 - 1040 (2021/02/09)
A facile method for the synthesis of indanones was developed under metal- and additive-free conditions, whereinl-proline served as an efficient and environmentally benign catalyst. Compared with previously synthesized indanones, synthesis by the transition-metal-catalyzed intramolecular hydroacylation of 2-vinylbenzaldehyde provided a more green synthetic pathway to indanone scaffolds with good to excellent yields. More importantly, it could be used to synthsize the anti-AD drug donepezil.
Preparation method of levobunolol hydrochloride
-
Paragraph 0041-0043-0044; 0048-0049; 0051-0052; 0054-0055, (2019/01/17)
The invention provides a preparation method of levobunolol hydrochloride. The preparation method comprises steps as follows: S-1-tert-butyl-epoxy methylamine and 1,2,3,4-tetrahydro-5-hydroxynaphthalen-1-one are subjected to a substitution reaction, and after acidizing treatment is performed, a target product, namely levobunolol hydrochloride, is prepared. With the adoption of the method, regioselectivity of the reaction is greatly improved, side reactions are avoided, yield of levobunolol hydrochloride is effectively increased, optical purity of levobunolol hydrochloride is effectively improved, yield reaches 87.3%, and ee value exceeds 99%.
Enantioselective halogenative semi-pinacol rearrangement: Extension of substrate scope and mechanistic investigations
Romanov-Michailidis, Fedor,Romanova-Michaelides, Maria,Pupier, Marion,Alexakis, Alexandre
supporting information, p. 5561 - 5583 (2015/03/30)
The present Full Paper article discloses a survey of our recent results obtained in the context of the enantioselective halogenation-initiated semi-pinacol rearrangement. Commencing with the fluorination/semi-pinacol reaction first and moving to the heavier halogens (bromine and iodine) second, the scope and limitations of the halogenative phase-transfer methodology will be discussed and compared. An extension of the fluorination/semi-pinacol reaction to the ring-expansion of five-membered allylic cyclopentanols will be also described, as well as some preliminary results on substrates prone to desymmetrization will be given. Finally, the present manuscript will culminate with a detailed mechanistic investigation of the canonical fluorination/semi-pinacol reaction. Our mechanistic discussion will be based on in situ reaction progress monitoring, complemented with substituent effect, kinetic isotopic effect and non-linear behaviour studies.