2836-32-0

Basic information

• Product Name: Sodium glycolate
• Synonyms: HYDROXYACETIC ACID SODIUM SALT;GLYCOLIC ACID SODIUM SALT;Aceticacid,hydroxy-,monosodiumsalt;glycolicacid,monosodiumsalt;glykokolansodny;hydroxy-aceticacimonosodiumsalt;monosodiumglycolate;natriumglykolat
• CAS NO: 2836-32-0
• Molecular Formula: C₂H₃O₃*Na
• Molecular Weight: 98.03
• EINECS: 220-624-9
• Product Categories: Pharmaceutical Intermediates
• Mol File: 2836-32-0.mol
• Article Data: 17

Chemical Properties

• Melting Point: 210-218℃
• Boiling Point: 265.6 °C at 760 mmHg
• Flash Point: 128.7 °C
• Appearance: White to off-white/Powder
• Density: 1.416 g/cm³
• Vapor Pressure: 0.00125mmHg at 25°C
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Water Solubility: Soluble
• CAS DataBase Reference: Sodium glycolate(CAS DataBase Reference)
• NIST Chemistry Reference: Sodium glycolate(2836-32-0)
• EPA Substance Registry System: Sodium glycolate(2836-32-0)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 24/25-26
• RTECS: MC5525000
• TSCA: Yes
• Hazardous Substances Data: 2836-32-0(Hazardous Substances Data)

Usage

Description

Sodium glycolate, an organic sodium salt, is a white to off-white powder that consists of equal numbers of sodium and glycolate ions. It is known for its various applications across different industries due to its unique chemical properties.

Uses

Used in Electroless Plating and Textile Finishing:
Sodium glycolate is used as a buffer in electrodeless plating and textile finishing, where it helps in stabilizing the pH and improving the overall process efficiency.
Used in Pharmaceutical Industry:
Sodium glycolate is used as a disintegrant, suspending agent, gelling agent, and buffering agent in the pharmaceutical grade for tablets and capsules. Its properties contribute to the improved formulation and performance of these medicinal products.
Used in Cosmetics and Personal Care Products:
In the cosmetics and personal care industry, sodium glycolate is utilized as an exfoliant, pH adjuster, skin-conditioning agent, and a flavoring agent. Its versatility in this sector allows for a wide range of applications, enhancing the quality and effectiveness of various products.

Purification Methods

Precipitate it from aqueous solution by adding EtOH and dry it in air. Also recrystallise it from H2O, where its solubility is 38% at 0o and 61% at100o. [Beilstein 3 III 370, 3 IV 573.]

InChI:InChI=1/C2H4O3.Na/c3-1-2(4)5;/h3H,1H2,(H,4,5);/q;+1/p-1

Upstream product

• 105-36-2 ethyl bromoacetate 
• 3926-62-3 sodium monochloroacetic acid 
• 79-14-1 glycolic Acid 
• 50-99-7 D-glucose 
• 9004-34-6 cellulose 
• 107-21-1 ethylene glycol 
• 56-81-5 glycerol 
• 7664-41-7 ammonia 
• 7440-23-5 sodium 
• 13094-51-4 bromoacetic anhydride 
• 40010-55-7 ¹³C-C₁-glucopyranose 
• 492-62-6 alpha-D-glucopyranose 
• 131543-46-9 Glyoxal 
• 79-11-8 chloroacetic acid 

Downstream Products

• 34128-01-3 trisodium 2-[(carboxymethyl)oxy]succinate 
• 938-36-3 1-methyl-2-phenylpyrrolidine 
• 76778-95-5 1-methyl-2-(hydroxymethyl)-2-phenylpyrrolidine 
• 64-18-6 formic acid 
• 110-15-6 succinic acid 
• 64-19-7 acetic acid 
• 102991-08-2 4-Methoxybenzyl 2-hydroxyacetate 
• 7782-53-8 copper(II) glycolate 
• 62-76-0 sodium oxalate 
• 94-75-7 2,4-Dichlorophenoxyacetic acid 
• 4856-97-7 2-(Hydroxymethyl)benzimidazole 
• 95734-82-0 nedaplatin 
• 167403-92-1 4-tert-butyl-N-(6-(2-hydroxyethoxy)-5-(2-methoxyphenyl)thio-4-pyrimidinyl)benzenesulfonamide 
• 146531-72-8 N-[6-(2-hydroxy-ethoxy)-5-(p-methoxyphenyl)-4-pyrimidinyl]-p-toluenesulfon-amide 

Relevant articles and documents

Homogeneous Reforming of Aqueous Ethylene Glycol to Glycolic Acid and Pure Hydrogen Catalyzed by Pincer-Ruthenium Complexes Capable of Metal–Ligand Cooperation

Glycolic acid is a useful and important α-hydroxy acid that has broad applications. Herein, the homogeneous ruthenium catalyzed reforming of aqueous ethylene glycol to generate glycolic acid as well as pure hydrogen gas, without concomitant CO2 emission, is reported. This approach provides a clean and sustainable direction to glycolic acid and hydrogen, based on inexpensive, readily available, and renewable ethylene glycol using 0.5 mol % of catalyst. In-depth mechanistic experimental and computational studies highlight key aspects of the PNNH-ligand framework involved in this transformation.

Preparation method for 2,4-dichlorophenoxyacetic acid

The invention provides a preparation method for 2,4-dichlorophenoxyacetic acid. The preparation method comprises the following steps: A) reacting a divalent salt of glycolic acid as shown in a formula(I) with 1,2,4-trichlorobenzene under the action of a catalyst so as to produce 2,4-dichlorophenoxyacetate as shown in a formula (II); and B) acidizing 2,4-dichlorophenoxyacetate so as to obtain 2,4-dichlorophenoxyacetic acid. According to the invention, 1,2,4-trichlorobenzene is creatively used for replacing phenol and chlorophenol and subjected to a condensation reaction with glycolate so as toproduce 2,4-dichlorophenoxyacetate, and hydrolysis is carried out so as to prepare 2,4-dichlorophenoxyacetic acid; so such a technical scheme effectively avoids the usage of phenol or chlorophenol, overcomes the problems of peculiar smell of an operation place and production of waste gas, waste water and industrial residues, greatly improves the operation environment of the operation place and produces good environmental protection benefits, and the reaction has high yield and purity.

Hydrolysis kinetics of chloroacetic acid with sodium hydroxide under strong alkaline conditions

The hydrolysis of chloroacetic acid and sodium hydroxide is carried out at 45-85 °C by using equal mole of sodium chloroacetate and alkali. Using reasonable approximation, the hydrolysis reaction is proved to be a second-order reaction when the conversion is less than 95 % and the kinetic rate coefficients are determined. The activate energy is calculated 103 kJ mol-1.