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28387-13-5

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28387-13-5 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 28387-13-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,8,3,8 and 7 respectively; the second part has 2 digits, 1 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 28387-13:
(7*2)+(6*8)+(5*3)+(4*8)+(3*7)+(2*1)+(1*3)=135
135 % 10 = 5
So 28387-13-5 is a valid CAS Registry Number.

28387-13-5Relevant articles and documents

Synthesis and evaluation of azalamellarin N and its A-ring-modified analogues as non-covalent inhibitors of the EGFR T790M/L858R mutant

Fukuda, Tsutomu,Anzai, Mizuho,Nakahara, Akane,Yamashita, Kentaro,Matsukura, Kazuaki,Ishibashi, Fumito,Oku, Yusuke,Nishiya, Naoyuki,Uehara, Yoshimasa,Iwao, Masatomo

supporting information, (2021/02/09)

Azalamellarin N, a synthetic lactam congener of the marine natural product lamellarin N, and its A-ring-modified analogues were synthesized and evaluated as potent and non-covalent inhibitors of the drug-resistant epidermal growth factor receptor T790M/L8

C-MET MODULATORS AND METHODS OF USE

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Page/Page column 203, (2008/06/13)

The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. More specifically, the invention provides quinazolines and quinolines which inhibit, regulate and/or modulate kinase receptor, particularly c-Met, KDR, c-Kit, flt-3 and flt-4, signal transduction pathways related to the changes in cellular activities as mentioned above, compositions which contain these compounds, and methods of using them to treat kinase-dependent diseases and conditions. The present invention also provides methods for making compounds as mentioned above, and compositions which contain these compounds.

New non peptidic C5a receptor antagonists

Astles, Peter C.,Brown, Thomas J.,Cox, Paul,Halley, Frank,Lockey, Peter M.,McCarthy, Clive,McLay, Iain M.,Majid, Tahir N.,Morley, Andrew D.,Porter, Barry,Ratcliffe, Andrew J.,Walsh, Roger J.A.

, p. 907 - 912 (2007/10/03)

A series of phenylguanidines which bind to the C5a receptor has been developed. The lead compound 1 (IC50 = 30 μM), discovered through random screening, has been modified to provide 32 (RPR121154) with submicromolar activity. This compound was

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