2840-00-8

Basic information

• Product Name: 4-Amino-3,5-dichloro-2,6-difluoropyridine
• Synonyms: 3,5-Dichloro-4-amino-2,6-difluoropyridine;3,5-DICHLORO-2,6-DIFLUORO-4-AMINOPYRIDINE;3,5-dichloro-2,6-difluoro-4-pyridinamine;3,5-DICHLORO-2,6-DIFLUOROPYRIDIN-4-AMINE;4-AMINO-3,5-DICHLORO-2,6-DIFLUOROPYRIDINE;1-AMINO-2,6-DICHLORO-3,5-DIFLUOROBENZENE;2,6-DICHLORO-3,5-DIFLUORO-4-AMINOPYRIDINE;TIMTEC-BB SBB000376
• CAS NO: 2840-00-8
• Molecular Formula: C₅H₂Cl₂F₂N₂
• Molecular Weight: 198.99
• EINECS: 220-630-1
• Product Categories: PYRIDINE
• Mol File: 2840-00-8.mol
• Article Data: 8

Chemical Properties

• Melting Point: 112-114 °C(lit.)
• Boiling Point: 281.7 °C at 760 mmHg
• Flash Point: 124.2 °C
• Appearance: white to light yellow crystal powder
• Density: 1.697 g/cm³
• Vapor Pressure: 0.0035mmHg at 25°C
• Refractive Index: 1.567
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• PKA: -3.04±0.10(Predicted)
• CAS DataBase Reference: 4-Amino-3,5-dichloro-2,6-difluoropyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Amino-3,5-dichloro-2,6-difluoropyridine(2840-00-8)
• EPA Substance Registry System: 4-Amino-3,5-dichloro-2,6-difluoropyridine(2840-00-8)

Safety Data

• Hazard Codes: Xn,N,Xi
• Statements: 21/22-51/53-36/37/38
• Safety Statements: 36/37-61-36-26
• RIDADR: UN 3077 9/PG 3
• WGK Germany: 2
• HazardClass: IRRITANT
• Hazardous Substances Data: 2840-00-8(Hazardous Substances Data)

Usage

Description

4-Amino-3,5-dichloro-2,6-difluoropyridine is an organic compound characterized by its white to light yellow crystal powder appearance. It serves as a crucial intermediate in the synthesis of various chemical compounds, including Fluroxypyr Ethyl Ester and Fluroxypyr (F598780), which are utilized in different industries.

Uses

Used in Chemical Synthesis:
4-Amino-3,5-dichloro-2,6-difluoropyridine is used as a key intermediate in the chemical synthesis industry for the production of various compounds. Its strategic position in the synthesis process allows for the creation of a wide range of products with diverse applications.
Used in Agricultural Chemicals:
In the agricultural chemicals industry, 4-Amino-3,5-dichloro-2,6-difluoropyridine is used as a precursor for the synthesis of Fluroxypyr Ethyl Ester and Fluroxypyr (F598780). These compounds are known for their herbicidal properties, making them valuable in controlling the growth of unwanted plants and ensuring the healthy development of crops.
Used in Pharmaceutical Research:
4-Amino-3,5-dichloro-2,6-difluoropyridine also holds potential in the pharmaceutical research field. Its unique chemical structure makes it a promising candidate for the development of new drugs and therapeutic agents, particularly in the areas of medicinal chemistry and drug design.

InChI:InChI=1/C5H2Cl2F2N2/c6-1-3(10)2(7)5(9)11-4(1)8/h(H2,10,11)

Upstream product

• 17723-18-1 4-azido-3,5-dichloro-2,6-difluoropyridine 
• 108-67-8 1,3,5-trimethyl-benzene 
• 2176-62-7 2,3,4,5,6-pentachloropyridine 
• 7664-41-7 ammonia 
• 1737-93-5 3,5-dichloro-2,4,6-trifluoropyridine 

Downstream Products

• 63489-58-7 4-amino-2,6-difluoropyridine 
• 405230-78-6 4-amino-3-chloro-2,6-difluoropyridine 
• 35622-80-1 4-Amino-3,5-dichlor-2-fluor-6-methoxypyridin 
• 69377-81-7 fluroxypyr 
• 35622-67-4 (2-Benzyloxy-3,5-dichloro-6-fluoro-pyridin-4-yl)-(3,5-dichloro-2,6-difluoro-pyridin-4-yl)-amine 
• 35622-42-5 (3,5-dichloro-2,6-difluoro-pyridin-4-yl)-(3,5-dichloro-2-fluoro-6-phenylsulfanyl-pyridin-4-yl)-amine 
• 35720-88-8 (3,5-dichloro-2,6-difluoro-pyridin-4-yl)-(3,5-dichloro-2-fluoro-6-phenoxy-pyridin-4-yl)-amine 
• 94133-62-7 4-amino-3,5-dichloro-6-fluoro-2-pyridinol 
• 1235471-31-4 3-[4-(trifluoromethyl)phenyl]isoxazole-5-carboxylic acid 3,5-dichloro-2,6-difluoropyridin-4-ylamide 
• 1235471-32-5 4,5-dihydro-3-[4-(trifluoromethyl)phenyl]isoxazole-5-carboxylic acid 3,5-dichloro-2,6-difluoropyridin-4-ylamide 
• 1020736-50-8 3,5-dichloro-2-fluoro-6-{3-[3-methyl-8-(trifluoromethyl)quinolin-4-yl]phenoxy}pyridin-4-amine 
• 35622-92-5 2-benzyloxy-3,5-dichloro-6-fluoro-pyridin-4-ylamine 
• 35622-93-6 3,5-dichloro-2-fluoro-6-phenoxy-pyridin-4-ylamine 
• 37756-56-2 (3,5-Dichloro-2,6-difluoro-pyridin-4-yl)-(5-fluoro-2,4-dinitro-phenyl)-amine 

Relevant articles and documents

Preparation method of 4-aminopyridine compound

The invention discloses a preparation method of a 4-aminopyridine compound. The preparation method comprises the following steps: adding a 4-amino- 3-chloropyridine compound or a 4-amino-3, 5-dichloropyridine compound, potassium phosphate and a catalyst into a solvent, and reacting at 0-10 MPa and 0-100 DEG C for 4-12 hours. According to the preparation method of the 4-aminopyridine compound, therelated raw materials are easy to obtain or self-make, the cost is low, the preparation method is simple, the reaction efficiency is high, the raw material cost is low, and byproducts have economic value; meanwhile, the reaction involved in the invention has good universality and tolerance to functional groups.

Three nitrogen heterocycle containing 1, 2, 3 - thiadiazole - 5 - a amidine compounds and synthesis

The invention discloses an N-trisubstituted-1,2,3-thiadiazole-5-formamidine compound with three aromatic rings of general formula TDCA and a synthesis method of N-trisubstituted-1,2,3-thiadiazole-5-formamidine compound. The target compound of general formula TDCA is obtained by reacting a compound of general formula B and a compound of general formula A, wherein references of X and Y in the general formula A are the same as those in the general formula TDCA.

Selective mono-and diamination of polyfluorinated benzenes and pyridines with liquid ammonia

Amination of pentafluoropyridine, 2,3,5,6-tetrafluoropyridine, 4-chlorotetrafluoropyridine, 3,5-dichlorotrifluoropyridine, octafluorotoluene, α,α,α,2,3,5,6-heptafluorotoluene, decafluoro-m-xylene, decafluorobiphenyl, hexafluorobenzene, and pentafluorobenzene with liquid ammonia was investigated. Bis-aminodefluorination temperatures for the majority of substrates were shown to exceed significantly the corresponding temperatures of monoaminodefluorination. The optimal conditions for selective preparation of mono-and diaminopolyfluoro(het)arenes were elucidated. An efficient method for isolation of particular polyfluorophenylenediamines from product mixtures formed in nonselective reactions of pentafluorobenzene and hexafluorobenzene with aqueous ammonia based on complexation with a crown ether is proposed.