2840-44-0

Basic information

• Product Name: 7-FLUORO-1-TETRALONE
• Synonyms: 7-FLUORO-3,4-DIHYDRO-2H-NAPHTHALEN-1-ONE;7-FLUORO-1-TETRALONE;7-Fluoro-α-Tetralone;7-FLUORO-A-TETRALONE;7-Fluoro-1-tetealone;7-Fluoro-2-tertralone;7-Fluoro-1-tetralone 97%
• CAS NO: 2840-44-0
• Molecular Formula: C₁₀H₉FO
• Molecular Weight: 164.18
• EINECS: 1312995-182-4
• Product Categories: Heterocycles series;Aromatic Building Blocks
• Mol File: 2840-44-0.mol
• Article Data: 16

Chemical Properties

• Melting Point: 61-66°C
• Boiling Point: 258.1 °C at 760 mmHg
• Flash Point: 99.5 °C
• Appearance: /
• Density: 1.198 g/cm³
• Vapor Pressure: 0.014mmHg at 25°C
• Refractive Index: 1.542
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 7-FLUORO-1-TETRALONE(CAS DataBase Reference)
• NIST Chemistry Reference: 7-FLUORO-1-TETRALONE(2840-44-0)
• EPA Substance Registry System: 7-FLUORO-1-TETRALONE(2840-44-0)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• WGK Germany: 2
• Hazardous Substances Data: 2840-44-0(Hazardous Substances Data)

Usage

Uses

7-Fluoro-1-tetralone is a useful research chemical.

Preparation

7-FLUORO-1-TETRALONE is an organic intermediate, which can be prepared from fluoro - benzene through a four-step reaction.

InChI:InChI=1/C10H9FO/c11-8-5-4-7-2-1-3-10(12)9(7)6-8/h4-6H,1-3H2

Upstream product

• 96-48-0 4-butanolide 
• 462-06-6 fluorobenzene 
• 22009-40-1 7-amino-1-tetralone 
• 32001-55-1 pyridine hydrogenfluoride 
• 51114-94-4 (2-carboxyethyl)triphenylphosphonium bromide 
• 127404-67-5 4-(3-fluoro-phenyl)-but-3-enoic acid 
• 69797-46-2 4-(3'-fluorophenyl)-4-oxo-butanoic acid 
• 70631-88-8 4-(3-fluorophenyl)butanoic acid 
• 3200-99-5 4-[4-(4-fluoro-phenyl)-butyryl]-thiomorpholine 
• 366-77-8 4-(4-fluorophenyl)-4-oxopropionic acid 
• 582-83-2 1-(4-fluorophenyl)butan-1-one 
• 17151-47-2 tributyl(4-fluorophenyl)stannane 
• 127404-66-4 4-(4-fluorophenyl)but-3-enoic acid 
• 133188-66-6 4-(4-fluorophenyl)butyryl chloride 

Downstream Products

• 376628-62-5 10-fluoro-2,4,6,7-tetrahydro-4-methyl-2-phenyl-3H-naphtho[2,1-c]azepin-3-one 
• 376628-55-6 7-fluoro-3,4-dihydro-1-(3'-phenylprop-1'-ynyl)naphthalene-2-carbaldehyde 
• 847173-36-8 8-fluoro-2,3,4,5-tetrahydro-1H-benzo[b]azepine 

Relevant articles and documents

Synthesis of Novel Pterocarpen Analogues via [3?+?2] Coupling-Elimination Cascade of α,α-Dicyanoolefins with Quinone Monoimines

By employing triethylamine as a catalyst, [3?+?2] coupling-elimination cascade of α,α-dicyanoolefins with quinone monoimines was realized. The reactions afforded various novel pterocarpen analogues with generally moderate yields (up to 75%). In addition, a plausible reaction mechanism was proposed.

Highly enantioselective [3+2] coupling of cyclic enamides with quinone monoimines promoted by a chiral phosphoric acid

Enantioselective [3+2] coupling of cyclic enamides with quinone monoimines was realised using a chiral phosphoric acid as a catalyst. This transformation allowed for the synthesis of highly enantioenriched polycyclic 2,3-dihydrobenzofurans (up to 99.9% ee). The absolute configuration of one product was determined by an X-ray crystal structural analysis. We also found a possible mechanism for this reaction.

Synthesis and structure-activity relationships of N-substituted spiropiperidines as nociceptin receptor ligands

A series of N-substituted analogs based upon the spiropiperidine core of 1 was synthesized and exhibited high binding affinity to the nociceptin (NOP) receptor. The selectivities against other known opioid receptors were determined.