2843-27-8

Basic information

• Product Name: 2-HYDROXYFORMANILIDE
• Synonyms: 2'-HYDROXYFORMANILIDE;2-HYDROXYFORMANILIDE;2-N-Formylaminophenol;N-(2-hydroxyphenyl)formamide;N-(2-hydroxyphenyl)methanamide
• CAS NO: 2843-27-8
• Molecular Formula: C₇H₇NO₂
• Molecular Weight: 137.14
• Mol File: 2843-27-8.mol
• Article Data: 53

Chemical Properties

• Boiling Point: 338.4°Cat760mmHg
• Flash Point: 158.4°C
• Appearance: /
• Density: 1.31g/cm³
• Vapor Pressure: 5.03E-05mmHg at 25°C
• Refractive Index: 1.644
• CAS DataBase Reference: 2-HYDROXYFORMANILIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-HYDROXYFORMANILIDE(2843-27-8)
• EPA Substance Registry System: 2-HYDROXYFORMANILIDE(2843-27-8)

Safety Data

• Hazardous Substances Data: 2843-27-8(Hazardous Substances Data)

Usage

Description

2-Hydroxyformanilide, also known as N-(2-Hydroxyethyl)formanilide, is a chemical compound with a molecular formula of C9H11NO2. It is a derivative of aniline formed by the reaction between formanilide and hydroxylamine. This white crystalline solid possesses properties that make it suitable for use as an intermediate in the production of various drugs and compounds. Additionally, it has been found to exhibit antifungal and antimicrobial properties, making it a promising compound for future pharmaceutical applications.

Uses

Used in Pharmaceutical Manufacturing:
2-Hydroxyformanilide is used as an intermediate in the production of various pharmaceuticals and organic compounds. Its unique properties allow it to be a key component in the synthesis of drugs and other chemical products.
Used in Antifungal Applications:
2-Hydroxyformanilide is used as an antifungal agent due to its ability to inhibit the growth of fungi. This makes it a potential candidate for use in treatments and products aimed at combating fungal infections.
Used in Antimicrobial Applications:
2-HYDROXYFORMANILIDE is also used as an antimicrobial agent, leveraging its capacity to suppress the growth of microorganisms. This quality positions 2-Hydroxyformanilide as a useful substance in applications where curbing microbial growth is necessary, such as in medical and hygiene products.

InChI:InChI=1/C7H7NO2/c9-5-8-6-3-1-2-4-7(6)10/h1-5,10H,(H,8,9)

Upstream product

• 273-53-0 benzoxazole 
• 529-23-7 o-aminobenzaldehyde 
• 30093-97-1 3,4,4-trimethyl-Δ²-oxazolinium iodide 
• 95-55-6 2-amino-phenol 
• 90965-27-8 Δ²-thiazolinium bromide 
• 90965-28-9 4,4-dimethyl-Δ²-oxazolinium chloride 
• 2258-42-6 formyl acetic anhydride 
• 16712-16-6 ammonium formate 
• 68-12-2 N,N-dimethyl-formamide 
• 51-19-4 2-aminophenol hydrochloride 
• 77287-34-4 formamide 
• 201230-82-2 carbon monoxide 
• 88-75-5 2-hydroxynitrobenzene 
• 89-73-6 salicylhydroxamic acid 

Downstream Products

• 219917-43-8 N-[2-(tert-Butyl-dimethyl-silanyloxy)-phenyl]-formamide 
• 273-53-0 benzoxazole 
• 1355021-61-2 N-(2-(2-tetrahydrofuranyloxy)phenyl)formamide 
• 1355021-62-3 N-(2-(2-tetrahydro-2H-pyranyloxy)phenyl)formamide 
• 1355021-59-8 N-(2-(2-bromo-1-ethoxyethoxy)phenyl)formamide 
• 1355021-58-7 N-(2-(1-ethoxypropyloxy)phenyl)formamide 
• 1355021-57-6 N-(2-(1-benzyloxyethoxy)phenyl)formamide 
• 1355021-74-7 1,6-bis(1-(2-formylaminophenoxy)ethoxy)hexane 
• 327618-31-5 2-(tetrahydrofuran-2-yl)benzoxazole 
• 1355021-30-5 1,6-bis(1-(2-isocyanophenoxy)ethoxy)hexane 
• 1355021-12-3 1-(1-ethoxyethoxy)-2-isocyanobenzene 
• 1355021-36-1 2-(1-benzyloxyethyl)benzo[d]oxazole 
• 1355021-13-4 1-(1-benzyloxyethoxy)-2-isocyanobenzene 
• 1355021-14-5 1-(1-ethoxypropoxy)-2-isocyanobenzene 

Relevant articles and documents

Metal-free N-formylation of 2-aminophenols using dimethylformamide and CSA

DMF has been proved to be an efficient formylation reagent for 2-aminophenols in the presence of (±) camphorsulfonic acid (CSA) in this work. CSA works as an acid catalyst and a neutralizer of dimethyl amine which is kicked off from DMF. Both electron-wit

Palladium supported on MRGO@CoAl-LDH catalyzed reductive carbonylation of nitroarenes and carbonylative Suzuki coupling reactions using formic acid as liquid CO and H2 source

In the present study, a heterogeneous palladium catalyst system, Pd nanoparticles supported on MRGO@CoAl-LDH, was synthesized and employed in reductive carbonylation of nitroarenes and carbonylative Suzuki coupling reactions using formic acid as CO and H2 source. The as-obtained heterogeneous catalyst was characterized by Fourier-transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), scanning electron microscopy (SEM), energy-dispersive X-ray analysis (EDAX), thermal gravimetric analysis (TGA), and vibrating sample magnetometer (VSM). The nanocatalyst was reused for 5 cycles with a negligible reduction in the yield of products. All reactions were carried out with high yields and under suitable and safe conditions. Also, we have successfully applied formic acid as a good and safe alternative to CO and H2 gases.

N-Formylation of amines using arylhydrazones of malononitrile and a Cu(II) complex under eco-friendly conditions at room temperature

In this work, we report the synthesis of formamides via solvent free N-formylation of amines using known arylhydrazones of malononitrile including sodium 2-(2-(dicyanomethylene)hydrazinyl)benzenesulfonate (I), 2-(2-(dicyanomethylene)hydrazinyl) benzoic acid (II) and its Cu(II) complex (III) as catalysts at room temperature. These catalysts are highly active and the scope of the method was investigated using several heterocyclic, aromatic and aliphatic amines as substrates, which produced the corresponding formamides in high yields. The remarkable advantages of this method are the elimination of toxic solvents, operational simplicity, easy workup procedure, excellent yields and avoidance of column chromatography.