28478-57-1

Basic information

• Product Name: 1-Pyrrolidinecarboxamide, N-(4-chlorophenyl)-2-oxo-
• CAS NO: 28478-57-1
• Molecular Formula: C11H11ClN2O2
• Molecular Weight: 238.674
• Mol File: 28478-57-1.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 1-Pyrrolidinecarboxamide, N-(4-chlorophenyl)-2-oxo-(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Pyrrolidinecarboxamide, N-(4-chlorophenyl)-2-oxo-(28478-57-1)
• EPA Substance Registry System: 1-Pyrrolidinecarboxamide, N-(4-chlorophenyl)-2-oxo-(28478-57-1)

Safety Data

• Hazardous Substances Data: 28478-57-1(Hazardous Substances Data)

Upstream product

• 616-45-5 2-pyrrolidinon 
• 104-12-1 p-chlorphenylisocyanate 
• 139926-35-5 1-(4-chlorophenylcarbamoyl)-2-oxopyrrolidine-3-carboxylic acid 
• 14468-90-7 N-trimethylsilyl-pyrrolidin-2-one 
• 55573-06-3 1-(4-chloro-phenylcarbamoyl)-2-oxo-pyrrolidine-3-carboxylic acid ethyl ester 
• 35640-09-6 N-(4-chlorophenyl)pyrrolidine-1-carboxamide 

Relevant articles and documents

Studies on pyrrolidinones. On the carbamoylation of some pyroglutamic derivatives

The carbamoylation of some lactams derivatived from pyroglutamic acid has been studied; better yields were obtained starting from the unsubstitued lactam (toluene, 80°) rather than starting with the N-silyllactam (room temperature), although these latter reaction conditions could be interesting for heat sensitive compounds. Methyl and phenyl isothiocyanate react only with the sodium salt of methyl pyroglutumate, giving 1,5-diaddition products.

Synthesis, decarboxylation, and nitrosation of 1-acyl-2-pyrrolidone-3-carboxylic acids: A convenient novel entry to 2,3-dioxopyrrolidine derivatives

Esters 1 of 1-acyl-2-pyrrolidone-3-carboxylic acids 2 were hydrolized to 2 with acetic acid/HCl at 60-70°C. Reaction of 1a with formic acid/HCl at 60-75°C led to (not isolated) 2a which began to decarboxylate to 3a during the conversion of 1a to 2a even a