28491-02-3

Basic information

• Product Name: 3-(4-CHLOROPHENOXY)PYRROLIDINE HYDROCHLORIDE
• Synonyms: 3-(4-CHLOROPHENOXY)PYRROLIDINE HYDROCHLORIDE
• CAS NO: 28491-02-3
• Molecular Formula: C₁₀H₁₂ClNO
• Molecular Weight: 197.66
• Mol File: 28491-02-3.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-(4-CHLOROPHENOXY)PYRROLIDINE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-CHLOROPHENOXY)PYRROLIDINE HYDROCHLORIDE(28491-02-3)
• EPA Substance Registry System: 3-(4-CHLOROPHENOXY)PYRROLIDINE HYDROCHLORIDE(28491-02-3)

Safety Data

• Hazardous Substances Data: 28491-02-3(Hazardous Substances Data)

Usage

Chemical class

Pyrrolidine derivative

Physical properties

White to off-white crystalline powder, soluble in water and methanol

Common uses

Pharmaceutical intermediate for drug synthesis

Additional applications

Building block for organic chemistry synthesis

Research areas

Study of effects on central nervous system, potential medical treatments

Upstream product

• 103057-44-9 N-(tert-butoxycarbonyl)-3-hydroxypyrrolidine 
• 106-48-9 4-chloro-phenol 
• 603-35-0 triphenylphosphine 

Downstream Products

• 356558-37-7 1-[3-(4-Chlorophenoxy)-1-pyrrolidinyl]-3-(5-methoxy-2-nitrophenoxy)-2-propanol 
• 356557-68-1 N-{2-[(3-{3-[(4-Chlorophenyl)oxy]-1-pyrrolidinyl}-2-hydroxy-1-methylpropyl)oxy]phenyl}acetamide hydrochloride 
• 356558-25-3 1-[3-(4-chlorophenoxy)-1-pyrrolidinyl]-3-(3,5-difluoro-2-nitrophenoxy)-2-propanol 
• 356557-08-9 N-(2-{3-[3-(4-Chlorophenoxy)-1-pyrrolidinyl]-2-hydroxy-2-methylpropoxy}phenyl)acetamide Hydrochloride 
• 356552-82-4 N-(2-{3-[3S-(4-Chloro-phenoxy)-pyrrolidin-1-yl]-2S-hydroxy-propoxy}-phenyl)-acetamide hydrochloride 
• 356558-21-9 1-[3-(4Chlorophenoxy)-1-pyrrolidinyl]-3-(5-methyl-2-nitrophenoxy)-2-propanol 

Relevant articles and documents

HETEROARYL DERIVATIVES OF FORMULA (I) AS ATF4 INHIBITORS

The invention is directed to substituted heteroaryl derivatives. Specifically, the invention is directed to compounds according to Formula (I) wherein A, C, D, L2, L3, R1, R2, R3, R4, R 5, R6, z2, z4, z5, and z6 are as defined herein; or salts thereof. The compounds of the invention are inhibitors of the ATF4 pathway and can be useful in the treatment of cancer, pre-cancerous syndromes and diseases associated with activated unfolded protein response pathways, such as Alzheimer's disease, spinal cord injury, traumatic brain injury, ischemic stroke, stroke, diabetes, Parkinson disease, Huntington's disease, Creutzfeldt-Jakob Disease, and related prion diseases, progressive supranuclear palsy, amyotrophic lateral sclerosis, myocardial infarction, cardiovascular disease, inflammation, fibrosis, chronic and acute diseases of the liver, chronic and acute diseases of the lung, chronic and acute diseases of the kidney, chronic traumatic encephalopathy (CTE), neurodegeneration, dementia, cognitive impairment, atherosclerosis, ocular diseases, arrhythmias, in organ transplantation and in the transportation of organs for transplantation. Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting the ATF4 pathway and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.