28659-81-6

Basic information

• Product Name: (S)-2-CHLORO-4-METHYL-N-VALERIC ACID
• Synonyms: Chloromethylvalericacid;(S)-2-CHLORO-4-METHYL-N-VALERIC ACID 96+%;(S)-2-CHLORO-4-METHY;(S)-2-Chloro-4-methylvaleric Acid;(S)-2-CHLORO-4-METHYL-N-VALERIC ACID;(S)-(-)-2-CHLORO 4-METHYLPENTANOIC ACID;(S)-2-CHLORO-4-METHYLPENTANOIC ACID;(S)-2-CHLORO-4-METHYLVALERIC ACID
• CAS NO: 28659-81-6
• Molecular Formula: C₆H₁₁ClO₂
• Molecular Weight: 150.6
• Product Categories: Building Blocks for Liquid Crystals;Carboxylic Acids (Chiral);Chiral Building Blocks;Chiral Compounds (Building Blocks for Liquid Crystals);Functional Materials;Synthetic Organic Chemistry
• Mol File: 28659-81-6.mol
• Article Data: 20

Chemical Properties

• Boiling Point: 126 °C / 30mmHg
• Flash Point: 91.7 °C
• Appearance: /
• Density: 1,09 g/cm3
• Vapor Pressure: 0.027mmHg at 25°C
• Refractive Index: 1.4410-1.4430
• PKA: 2.98±0.21(Predicted)
• CAS DataBase Reference: (S)-2-CHLORO-4-METHYL-N-VALERIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-2-CHLORO-4-METHYL-N-VALERIC ACID(28659-81-6)
• EPA Substance Registry System: (S)-2-CHLORO-4-METHYL-N-VALERIC ACID(28659-81-6)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 28659-81-6(Hazardous Substances Data)

Usage

General Description

(S)-2-Chloro-4-methyl-N-valeric acid, also known as HMG-CoA reductase inhibitor, is a chemical compound that is used in the pharmaceutical industry for the treatment of high cholesterol and other lipid disorders. It works by inhibiting the enzyme HMG-CoA reductase, which is involved in the biosynthesis of cholesterol. By blocking this enzyme, the compound helps to lower the levels of cholesterol in the blood, thereby reducing the risk of heart disease and stroke. It is commonly used as a medication in the form of tablets or injections, and is available under various brand names. The compound is generally well-tolerated, but may cause side effects such as muscle pain, liver problems, and digestive issues in some individuals. Overall, (S)-2-Chloro-4-methyl-N-valeric acid is an important and widely used medication for managing high cholesterol and improving cardiovascular health.

InChI:InChI=1/C6H11ClO2/c1-4(2)3-5(7)6(8)9/h4-5H,3H2,1-2H3,(H,8,9)/t5-/m0/s1

Upstream product

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• 161661-14-9 1-<1,2;5,6-di-O-(1-methylethylidene)-α-D-glucofuranosyloxy>-1-trimethylsilyloxy-4-methyl-pent-1-ene 
• 139193-63-8 1,2;5,6-di-O-(1-methylethylidene)-α-D-glucofuranosyl 4-methyl pentanoate 
• 646-07-1 4-Methylpentanoic acid 
• 61-90-5 L-leucine 

Downstream Products

• 541-46-8 isobutylamide 
• 111505-48-7 4-Nitro-benzoic acid (R)-1-tert-butoxycarbonyl-ethyl ester 
• 76379-09-4 benzyl 2-acetamido-4,6-O-benzylidene-3-O-<1-(R)-carboxyisopentyl>-2-deoxy-α-D-glucopyranoside 
• 143238-70-4 2'-<6'-((2''S-2''-chloro-4''-methylpentanoyl)oxy)>naphthyl 4-decyloxybenzoate 
• 111505-51-2 4-Nitro-benzoic acid (R)-1-tert-butoxycarbonyl-3-methyl-butyl ester 
• 1190832-59-7 C₁₂H₁₇ClN₂O 
• 1599459-87-6 (2S)-2-(2′-chloro-4′-methylpentanamido)-4-chlorobenzoic acid 
• 1599459-89-8 (2S)-2-(2′-chloro-4′-methylpentanamido)-5-bromobenzoic acid 

Relevant articles and documents

Enantioselective CC bond reduction of unsaturated α-chloro esters by old yellow enzymes

The reduction of the CC double bond of some unsaturated α-chloro esters was investigated by means of cloned and overexpressed enoate reductases. The results were compared with those obtained by employing baker's yeast whole cells. The anti stereochemistry of hydrogen additions was confirmed by deuterium labeling experiments.

Chiral Pool-Based Synthesis of Naphtho-Fused Isocoumarins

A variety of chiral derivatives of benzo[d]naphtho[1,2-b]pyran-6-one were prepared in a single step by Et3N-mediated condensation of homophthalic anhydride with different derivatives of (S)-amino acid chlorides at -5 °C by employing a chiral pool methodology. Chirality 27:951-957, 2015.

Stereoselective synthesis of (3r)-3-alkyl-4,1-benzoxazepine-2,5-diones

Novel 3-alkyl-4,1-benzoxazepine-2,5-diones were synthesized in good ee exploiting the chiral pool methodology, an economical way of asymmetric synthesis. Various anthranilic acids are coupled with different α-haloacids to afford N-acylated anthranilic aci