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2868-48-6

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2868-48-6 Usage

Description

HYODEOXYCHOLIC ACID METHYL ESTER is a light yellow solid that is a cholesterol derivative with hemolytic properties. It is known for its ability to inhibit the oxidation of cholesterol, making it a potentially useful compound in the field of pharmaceuticals and healthcare.

Uses

Used in Pharmaceutical Industry:
HYODEOXYCHOLIC ACID METHYL ESTER is used as a cholesterol-lowering agent for its ability to inhibit the oxidation of cholesterol. This application is particularly relevant in the treatment and management of conditions related to high cholesterol levels, such as atherosclerosis and cardiovascular diseases.
Used in Research and Development:
As a cholesterol derivative with hemolytic properties, HYODEOXYCHOLIC ACID METHYL ESTER can be used in research and development for studying the effects of cholesterol oxidation and its role in various diseases. This can lead to the development of new therapeutic strategies and drug candidates targeting cholesterol-related conditions.
Used in Drug Delivery Systems:
Similar to gallotannin, HYODEOXYCHOLIC ACID METHYL ESTER could potentially be incorporated into drug delivery systems to enhance its bioavailability and therapeutic outcomes. This application could involve the use of organic or metallic nanoparticles as carriers for the compound, aiming to improve its delivery and efficacy in treating cholesterol-related conditions.

Check Digit Verification of cas no

The CAS Registry Mumber 2868-48-6 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,8,6 and 8 respectively; the second part has 2 digits, 4 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 2868-48:
(6*2)+(5*8)+(4*6)+(3*8)+(2*4)+(1*8)=116
116 % 10 = 6
So 2868-48-6 is a valid CAS Registry Number.
InChI:InChI=1/C25H42O4/c1-15(5-8-23(28)29-4)18-6-7-19-17-14-22(27)21-13-16(26)9-11-25(21,3)20(17)10-12-24(18,19)2/h15-22,26-27H,5-14H2,1-4H3/t15-,16-,17+,18-,19+,20+,21+,22+,24-,25-/m1/s1

2868-48-6 Well-known Company Product Price

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  • (Code)Product description
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  • Detail
  • TCI America

  • (H0529)  Methyl Hyodeoxycholate  >98.0%(GC)

  • 2868-48-6

  • 5g

  • 1,550.00CNY

  • Detail
  • TCI America

  • (H0529)  Methyl Hyodeoxycholate  >98.0%(GC)

  • 2868-48-6

  • 25g

  • 4,500.00CNY

  • Detail
  • Sigma

  • (H2517)  Hyodeoxycholic acid methyl ester  ≥98%

  • 2868-48-6

  • H2517-1G

  • 444.60CNY

  • Detail

2868-48-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 11, 2017

Revision Date: Aug 11, 2017

1.Identification

1.1 GHS Product identifier

Product name methyl (4R)-4-[(3R,5R,6S,8S,9S,10R,13R,14S,17R)-3,6-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoate

1.2 Other means of identification

Product number -
Other names 3|A,6|A-Dihydroxy-5|A-cholan-24-oic acid methyl ester

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:2868-48-6 SDS

2868-48-6Relevant articles and documents

Synthesis of 5α-cholestan-6-one derivatives and their inhibitory activities of NO production in activated microglia: Discovery of a novel neuroinflammation inhibitor

Yang, Ya-Xi,Zheng, Long-Tai,Shi, Jing-Jing,Gao, Bo,Chen, Yan-Ke,Yang, Hui-Chi,Chen, Hong-Li,Li, Yuan-Chao,Zhen, Xue-Chu

, p. 1222 - 1227 (2014)

Glial activation-mediated neuroinflammation plays a pivotal role in the process of several neuroinflammatory diseases including stroke, Alzheimer's diseases, Parkinson's diseases, multiple sclerosis and ischemia. Inhibition of microglial activation may ameliorate neuronal degeneration under the inflammatory conditions. In the present study, a number of 5α-cholestan-6- one derivatives were prepared and the anti-inflammatory effects of these compounds were evaluated in LPS-stimulated BV-2 microglia cells. Those derivatives were synthesized from readily available hyodeoxycholic acid (1). Among the tested compounds, several analogs (16-18, 25, 35, 38) exhibited potent inhibitory activities on nitric oxide production with no or weak cell toxicity. Compound 16 also significantly suppressed the expression of TNF-α, interleukin (IL)-1β, cyclooxygenase (COX-2) as well as inducible nitric oxide synthase (iNOS) in LPS-stimulated BV-2 microglia cells. In addition, compound 16 markedly reduced infarction volume in a focal ischemic mice model.

METHOD FOR HOMOGENIZING BILE ACID DERIVATIVES

-

Paragraph 0083-0085, (2021/05/28)

The present invention relates to a process for producing bile acid derivatives having a protected hydroxyl group in the 3 position comprising contacting a bile acid derivative having an unprotected 3-alpha-hydroxyl group with a specific lipase. The present invention further relates to a bile acid derivative obtained or obtainable by the process, to the use of the bile acid derivative obtained or obtainable by the process for producing lithocholic acid and also to a process for producing lithocholic acid and to lithocholic obtained by the process. The invention further relates to the use of lithocholic acid obtained or obtainable by the process for producing ursodeoxycholic acid or ursodeoxycholic acid derivatives.

Efficient synthesis of cholic acid derivates through stereoselective C–H functionalization from hyodeoxycholic acid

Liang, Yu-Yan,Huang, Huan,Li, Yang,Du, Rong-Kai,Li, Jing,Liu, Yong-Hong,Li, Shan,Zhang, Lei

, (2020/02/26)

Five cholic acid derivatives (including allo-ω-muricholic acid and CDCA) were synthesized from hyodeoxycholic acid via selective oxidation of C3- or C6-hydroxyl groups by IBX and NBS oxidants and stereocontrolled conversion. The hydroxyl group could be introduced through hydrolyzing α-Br keto with K2CO3 aqueous solution or through oxidizing the double bond by monoperoxyphthalic acid. The reduction of C6-O6 carbonyl to methylene could undergo with PTSH, NaBH3CN and ZnCl2 only at 5β configuration. A feasible synthetic route of CDCA from HDCA has been established to avoid the epimerization with the yield of 45% (8 steps). These strategies provided good yields, stereoselectivity and reproducibility for the preparation of cholic acid derivates and CDCA.

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