287208-66-6

Basic information

• Product Name: 1-iodo-4-(iodomethyl)benzene
• Synonyms: 1-iodo-4-(iodomethyl)benzene
• CAS NO: 287208-66-6
• Molecular Weight: 343.934
• Mol File: 287208-66-6.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 1-iodo-4-(iodomethyl)benzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-iodo-4-(iodomethyl)benzene(287208-66-6)
• EPA Substance Registry System: 1-iodo-4-(iodomethyl)benzene(287208-66-6)

Safety Data

• Hazardous Substances Data: 287208-66-6(Hazardous Substances Data)

Usage

1-Iodo-4-(iodomethyl)benzene Properties

A chemical compound consisting of 7 carbon atoms, 6 hydrogen atoms, and 2 iodine atoms.
2. Derivative of benzene
A compound based on the benzene structure, which is a six-carbon ring with alternating single and double bonds.
3. Iodine atoms attached at positions 1 and 4
Two iodine atoms are connected to the benzene ring at the first and fourth carbon atoms, giving the compound its characteristic properties.
4. Methyl group attached to position 4
A single carbon atom with three hydrogen atoms is connected to the fourth carbon atom of the benzene ring, further modifying the compound's properties.
5. Organic synthesis use
The compound is used in the synthesis of other organic compounds, serving as a building block for more complex molecules.
6. Intermediate in pharmaceutical production
It serves as a precursor in the production of pharmaceuticals, aiding in the creation of various drugs and medications.
7. Reagent in chemical reactions
1-Iodo-4-(iodomethyl)benzene is used as a reagent in reactions such as cross-coupling, arylations, and nucleophilic substitutions.
8. Medicinal chemistry building block
The compound is a valuable resource in medicinal chemistry, used to develop new drug candidates and therapeutic agents.
9. Toxicity and irritation hazards
Proper handling is required, as the compound can be toxic and may cause skin and eye irritation upon contact.

Upstream product

• 18282-51-4 4-iodo-benzyl alcohol 
• 624-31-7 4-tolyl iodide 
• 623-04-1 4-aminobenzenemethanol 
• 124129-83-5 diphosphoric acid tetrakis-(4-iodo-benzyl ester) 
• 60599-65-7 phosphoric acid tris-(4-iodo-benzyl ester) 
• 16004-15-2 1-bromomethyl-4-iodobenzene 

Downstream Products

• 1612770-50-9 1,8-bis(4-iodobenzyloxy)-3-methylanthracene-9, 10-dione 
• 1370590-04-7 ethyl (E)-5-(4-((E)-3-ethoxy-3-oxoprop-1-en-1-yl)phenyl)pent-2-enoate 
• 1370590-19-4 ethyl 5-(4-(3-ethoxy-3-oxoprop-1-en-1-yl)phenyl)pent-2-enoate 
• 287208-43-9 5,11,17,23-tetrakis(1,1-dimethylethyl)-25-(4-iodobenzyloxy)-26,27,28-trihydroxycalix[4]arene 

Relevant articles and documents

Method for preparing benzyl iodide and derivatives thereof

The invention discloses a method for efficiently preparing benzyl iodide and derivatives thereof. The preparation method is characterized in that a benzyl alcohol compound, iodine and hydrogen are used as the reaction raw materials and rhodium and phosphine ligand are used as the catalyst to perform one-step reaction in an organic solvent under a positive pressure condition to synthesize the target benzyl iodide and the derivatives thereof, and the reaction formula of the reaction is as shown in the specification. The method has the advantages that the iodination of the method can be easily achieved, reaction condition requirements are low, large-scale industrial production can be achieved, the yield of the benzyl iodide can reach 82% or above, and the yield of the derivatives of the benzyl iodide can reach 99% or above; the method is wide in application range, short in process flow, low in raw material cost and applicable to the industrial production of a series of benzyl iodide and the derivatives thereof.

N-Hydroxyphthalimide-Mediated Electrochemical Iodination of Methylarenes and Comparison to Electron-Transfer-Initiated C-H Functionalization

An electrochemical method has been developed for selective benzylic iodination of methylarenes. The reactions feature the first use of N-hydroxyphthalimide as an electrochemical mediator for C-H oxidation to nonoxygenated products. The method provides the basis for direct (in situ) or sequential benzylation of diverse nucleophiles using methylarenes as the alkylating agent. The hydrogen-atom transfer mechanism for C-H iodination allows C-H oxidation to proceed with minimal dependence on the substrate electronic properties and at electrode potentials 0.5-1.2 V lower than that of direct electrochemical C-H oxidation.

Electron paramagnetic resonance spectroscopic characterization of α,2-and α,4-didehydrotoluene

The elusive diradicals α,2-and α,4-didehydrotoluene 1 and 3, have been generated by photolysis of matrix-isolated 2-iodobenzyl iodide 7 and 4-iodobenzyl iodide 8, respectively. Diradical 3 could also be synthesized by flash vacuum thermolysis of 8, with s