287379-37-7

Basic information

• Product Name: 4-[(4-But-2-ynyloxy-benzenesulfonyl)-methyl-amino]-8-methoxy-quinoline-3-carboxylic acid ethyl ester
• CAS NO: 287379-37-7
• Molecular Weight: 468.53
• Mol File: 287379-37-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 4-[(4-But-2-ynyloxy-benzenesulfonyl)-methyl-amino]-8-methoxy-quinoline-3-carboxylic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-[(4-But-2-ynyloxy-benzenesulfonyl)-methyl-amino]-8-methoxy-quinoline-3-carboxylic acid ethyl ester(287379-37-7)
• EPA Substance Registry System: 4-[(4-But-2-ynyloxy-benzenesulfonyl)-methyl-amino]-8-methoxy-quinoline-3-carboxylic acid ethyl ester(287379-37-7)

Safety Data

• Hazardous Substances Data: 287379-37-7(Hazardous Substances Data)

Upstream product

• 27568-05-4 4-Chloro-8-methoxyquinoline-3-carboxylic acid ethyl ester 
• 287379-32-2 4-But-2-ynyloxy-N-methyl-benzenesulfonamide 
• 87-13-8 diethyl 2-ethoxymethylenemalonate 
• 27568-04-3 Ethyl 4-hydroxy-8-methoxyquinoline-3-carboxylate 
• 90-04-0 2-methoxy-phenylamine 

Downstream Products

• 287379-38-8 4-[(4-but-2-ynyloxy-benzenesulfonyl)-methylamino]-8-methoxy-quinoline-3-carboxylic acid 

Relevant articles and documents

Preparation and use of acetylenic ortho-sulfonamido and phosphinic acid amido bicyclic heteroaryl hydroxamic acids as TACE inhibitors

Compounds of the formula which are useful in disease conditions mediated by TNF-α, such as rheumatoid arthritis, osteoarthritis, sepsis, AIDS, ulcerative colitis, multiple sclerosis, Crohn's disease and degenerative cartilage loss.

ACETYLENIC ORTHO-SULFONAMIDO AND PHOSPHINIC ACID AMIDO BICYCLIC HETEROARYL HYDROXAMIC ACIDS AS TACE INHIBITORS

Compounds of the formula are provided wherein P and Q are provided that when P is Q is and vice versa; which are useful in disease conditions mediated by TNF- alpha , such as rheumatoid arthritis, osteoarthritis, sepsis, AIDS, ulcerative colitis, multiple sclerosis, Crohn's disease and degenerative cartilage loss.