287383-59-9 Usage
Description
SCRIPTAID is a histone deacetylase (HDAC) inhibitor that enhances global acetylation of histones, improving transcriptional activity and protein expression. It has an optimal concentration of 6-8 μM in a cell-based assay, is less toxic than trichostatin A, and works in a wide variety of biological systems. SCRIPTAID inhibits tumor growth, decreases telomerase activity, and stimulates glioma cell apoptosis.
Uses
Used in Pharmaceutical Industry:
SCRIPTAID is used as a histone deacetylase inhibitor for its ability to facilitate transcriptional activation (TGFβ/Smad4) in both stable and transient receptor assays in a concentration-dependent manner.
Used in Cancer Research:
SCRIPTAID is used as an anticancer agent, inhibiting tumor growth in vitro and in vivo, and inducing cell cycle arrest in colon cancer cells in culture.
Used in Reproductive Biology:
SCRIPTAID is used in post-activation of oocytes and embryo culture, facilitating the cloning of inbred mouse strains produced by somatic cell nuclear transfer.
Biological Activity
Novel histone deacetylase inhibitor. Produces > 100-fold increase in histone acetylation and displays relatively low toxicity.
Biochem/physiol Actions
Histone deacetylase inhibitor with lower toxicity than trichostatin A; used to enhance protein expression.
References
1) Su?et al.?(2000),?A novel histone deacetylase inhibitor identified by high-throughput transcriptional screening of a compound library; Cancer Res.,?60?3137
2) Huber?et al.?(2011),?Inhibitors of histone deacetylases: correlation between isoform specificity and reactivation of HIV type 1 (HIV-1) from latently infected cells; J. Biol. Chem.,?286?22211
3) Lee?et al.?(2008),?Histone deacetylase inhibitor scriptaid induces cell cycle arrest and epigenetic change in colon cancer cells; J. Oncol.,?33?767
4) Rissi?et al.?(2019),?Inhibition of RNA synthesis during Scriptaid exposure enhances gene reprogramming in SCNT embryos; Reproduction,?157?123
5) Huang?et al.?(2020),?Scriptaid/exercise-induced lysine acetylation is another type of posttranslational modification occurring in titin; J. Appl. Physiol.,?128?276
Check Digit Verification of cas no
The CAS Registry Mumber 287383-59-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,8,7,3,8 and 3 respectively; the second part has 2 digits, 5 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 287383-59:
(8*2)+(7*8)+(6*7)+(5*3)+(4*8)+(3*3)+(2*5)+(1*9)=189
189 % 10 = 9
So 287383-59-9 is a valid CAS Registry Number.
InChI:InChI=1/C18H18N2O4/c21-15(19-24)10-2-1-3-11-20-17(22)13-8-4-6-12-7-5-9-14(16(12)13)18(20)23/h4-9,24H,1-3,10-11H2,(H,19,21)
287383-59-9Relevant articles and documents
FILAGGRIN PRODUCTION PROMOTER, THERAPEUTIC AGENT FOR DISEASES ASSOCIATED WITH REDUCTION IN PRODUCTION OF FILAGGRIN, AND METHOD FOR SCREENING FOR SAID THERAPEUTIC AGENT
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Page/Page column, (2015/06/16)
The present invention provides a highly effective substance having a filaggrin production-promoting action. The present invention also provides a therapeutic agent useful for treating a skin disease, in particular, atopic dermatitis associated with reduce
A convenient synthesis of the new histone deacetylase inhibitor scriptaid
Gerova, Mariana S.,Petrov, Ognyan I.
, p. 76 - 79 (2014/03/21)
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