287407-57-2

Basic information

• Product Name: (R)-methyl 2-(fluorenylmethoxycarbonyl)amino-2-(4-hydroxyphenyl)-acetic acid methyl ester
• Synonyms: (R)-methyl 2-(fluorenylmethoxycarbonyl)amino-2-(4-hydroxyphenyl)-acetic acid methyl ester
• CAS NO: 287407-57-2
• Molecular Weight: 403.434
• Mol File: 287407-57-2.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: (R)-methyl 2-(fluorenylmethoxycarbonyl)amino-2-(4-hydroxyphenyl)-acetic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-methyl 2-(fluorenylmethoxycarbonyl)amino-2-(4-hydroxyphenyl)-acetic acid methyl ester(287407-57-2)
• EPA Substance Registry System: (R)-methyl 2-(fluorenylmethoxycarbonyl)amino-2-(4-hydroxyphenyl)-acetic acid methyl ester(287407-57-2)

Safety Data

• Hazardous Substances Data: 287407-57-2(Hazardous Substances Data)

Upstream product

• 37763-23-8 D-2-p-hydroxyphenylglycine methyl ester 
• 82911-69-1 N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide 
• 57591-61-4 methyl (R)-2-amino-2-(4-hydroxyphenyl)acetate hydrochloride 
• 22818-40-2 D-4-hydroxyphenylglycine 
• 28920-43-6 (fluorenylmethoxy)carbonyl chloride 
• 43189-12-4 (R)-methyl 2-amino-2-(4-hydroxyphenyl)acetate 

Downstream Products

• 608518-57-6 (R)-(4-But-2-ynyloxy-benzenesulfonylamino)-[4-(2-methylamino-ethoxy)-phenyl]-acetic acid 

Relevant articles and documents

Intermediate of RORgamma inhibitor and preparation method thereof

The invention belongs to the technical field of drugs, in particular to an intermediate of a RORgamma inhibitor and a preparation method thereof. The intermediate is as shown in a formula (I). The method has the advantages of being easily available in raw material, concise in process, economic and environment-friendly, high in yield and the like. The formula is as shown in the description.

ACETYLENIC ALPHA-AMINO ACID-BASED SULFONAMIDE HYDROXAMIC ACID TACE INHIBITORS

Compound of the formula (B) are useful in treating disease conditions mediated by TNF- alpha , such as rheumatoid arthritis, osteoarthritis, sepsis, AIDS, ulcerative colitis, multiple sclerosis, Crohn's disease and degenerative cartilage loss.