28749-88-4

Basic information

• Product Name: 1,2-Benzenedicarboxylic acid, 3,4,6-trifluoro-5-hydroxy-
• CAS NO: 28749-88-4
• Molecular Formula: C8H3F3O5
• Molecular Weight: 236.104
• Mol File: 28749-88-4.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: 1,2-Benzenedicarboxylic acid, 3,4,6-trifluoro-5-hydroxy-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2-Benzenedicarboxylic acid, 3,4,6-trifluoro-5-hydroxy-(28749-88-4)
• EPA Substance Registry System: 1,2-Benzenedicarboxylic acid, 3,4,6-trifluoro-5-hydroxy-(28749-88-4)

Safety Data

• Hazardous Substances Data: 28749-88-4(Hazardous Substances Data)

Usage

Explanation

The molecular formula represents the number of atoms of each element present in a molecule of the compound.
2. Derivative of benzenedicarboxylic acid (phthalic acid)

Explanation

1,2-Benzenedicarboxylic acid, 3,4,6-trifluoro-5-hydroxyis derived from benzenedicarboxylic acid by substituting hydrogen atoms with fluorine and hydroxy groups.

Explanation

The compound has three fluorine atoms replacing hydrogen atoms in the benzene ring.

Explanation

The compound contains a single hydroxy (-OH) group attached to the benzene ring.

Explanation

The compound is used as a building block in the synthesis of various pharmaceuticals and agrochemicals, as well as a reagent in chemical reactions and a component in materials science research.

Explanation

The unique combination of fluorine and hydroxy substituents in the compound may contribute to its potential biological activity, making it of interest for further study.

Explanation

The compound's properties, including its fluorine and hydroxy substituents, suggest that it may have potential applications in various industries, although specific applications may need further investigation.

Fluorine substituents

Three

Hydroxy group

One

Applications

Pharmaceutical and agrochemical synthesis, reagent in chemical reactions, materials science research

Biological activity

Potential

Industrial applications

Potential

Upstream product

• 1835-65-0 Tetrafluorophthalonitrile 
• 652-03-9 3,4,5,6-tetrafluorophthalic acid 
• 652-12-0 4,5,6,7-tetrafluoroisobenzofuran-1,3-dione 
• 122180-11-4 octafluoro-1,3-dihydroisobenzofuran 

Downstream Products

• 116751-24-7 2,4,5-trifluoro-3-hydroxybenzoic acid 
• 136897-64-8 methyl 3-methoxy-2,4,5-trifluorobenzoate 

Relevant articles and documents

TAU-PROTEIN TARGETING COMPOUNDS AND ASSOCIATED METHODS OF USE

The present disclosure relates to bifunctional compounds, which find utility as modulators of tan protein. In particular, the present disclosure is directed to bifunctional compounds, which contain on one end a VHL or cereblon ligand which binds to the E3 ubiquitin ligase and on the other end a moiety which binds tan protein, such that tan protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of tan. The present disclosure exhibits a broad range of pharmacological activities associated with degradation/inhibition of tan protein. Diseases or disorders that result from aggregation or accumulation of tan protein are treated or prevented with compounds and compositions of the present disclosure.

A polymer-supported chiral fluorinated dirhodium(II) complex for asymmetric amination of silyl enol ethers

The immobilization of dirhodium(II) tetrakis[N-tetrafluorophthaloyl-(S)- tert-leucinate], [Rh2(S-TFPTTL)4], has been accomplished by copolymerization of a dirhodium(II) complex-containing monomer with styrene and 1,6-bis(4-vinylbenzyloxy)hexane as a flexible cross-linker. The polymer-supported chiral fluorinated dirhodium(II) complex catalyzed the amination of silyl enol ethers with [N-(2-nitrophenylsulfonyl)imino] phenyliodinane (NsN=IPh) to provide α-amino ketones in high yields with high levels of enantioselectivity and could be used up to 20 times as the catalyst readily withstood stirring in the presence of the solid reactant. Copyright

Process improvements in the synthesis of 2,4,5-trifluorobenzoic acid. selective hydrodefluorination of tetrafluorophthalimides

An improved preparation of the fluoroquinolone antibacterial intermediate 2,4,5-trifluorobenzoic acid is described. A combination of a selective hydrodefluorination and hydrolysis reaction of 3,4,5,6-tetrafluoro-N-methylphthalimide leading to 3,5,6-trifluorophthalic acid was key to the success of the process. In addition the development of a two-step, one-pot imidization/ halogen exchange from tetrachlorophthalic anhydride to 3,4,5,6-tetrafluoro-N-methylphthalimide in sulfolane solvent is detailed.