2879-83-6

Basic information

• Product Name: N-(4-BROMO-PHENYL)-BENZAMIDE
• Synonyms: BENZYL-(4-BROMO-PHENYL)-AMINE;N-(4-BROMO-PHENYL)-BENZAMIDE;Benzenemethanamine, N-(4-bromophenyl)-
• CAS NO: 2879-83-6
• Molecular Formula: C₁₃H₁₂BrN
• Molecular Weight: 276.13
• Product Categories: pharmacetical
• Mol File: 2879-83-6.mol
• Article Data: 157

Chemical Properties

• Melting Point: 51-52 °C
• Boiling Point: 293.1°Cat760mmHg
• Flash Point: 131°C
• Appearance: /
• Density: 1.496g/cm³
• Vapor Pressure: 0.00176mmHg at 25°C
• Refractive Index: 1.665
• PKA: 3.18±0.20(Predicted)
• CAS DataBase Reference: N-(4-BROMO-PHENYL)-BENZAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-BROMO-PHENYL)-BENZAMIDE(2879-83-6)
• EPA Substance Registry System: N-(4-BROMO-PHENYL)-BENZAMIDE(2879-83-6)

Safety Data

• Hazardous Substances Data: 2879-83-6(Hazardous Substances Data)

Usage

General Description

N-(4-Bromo-phenyl)-benzamide is a chemical compound with the molecular formula C13H10BrNO. It is a benzamide derivative with a 4-bromo-phenyl group attached to the amide functional group. N-(4-BROMO-PHENYL)-BENZAMIDE is often used as a building block in organic synthesis, particularly in the production of pharmaceuticals and agrochemicals. It has potential applications in the development of new drugs and bioactive compounds due to its structural properties and reactivity. Additionally, it may also be used as a research tool in organic chemistry and medicinal chemistry studies. However, as with all chemicals, it should be handled and used with appropriate caution and in accordance with safety guidelines.

InChI:InChI=1/C13H10BrNO/c14-11-6-8-12(9-7-11)15-13(16)10-4-2-1-3-5-10/h1-9H,(H,15,16)

Upstream product

• 780-20-1 N-benzylidene-4-bromoaniline 
• 108-88-3 toluene 
• 106-40-1 4-bromo-aniline 
• 1750-23-8 4-bromo-N-[(E)-phenylmethylidene]aniline 
• 100-52-7 benzaldehyde 
• 62-53-3 aniline 
• 100-39-0 benzyl bromide 
• 586-78-7 para-nitrophenyl bromide 
• 55962-05-5 [N-(p-tolylsulfonyl)imino]phenyliodinane 
• 65145-14-4 N,N-dibenzyl-4-bromoaniline 
• 5467-74-3 4-Bromophenylboronic acid 
• 622-30-0 N-benzyl hydroxylalmine 
• 13292-87-0 dimethylsulfide borane complex 
• 98-88-4 benzoyl chloride 

Downstream Products

• 1341155-75-6 C₁₇H₁₄BrN₃O₂ 
• 1341156-19-1 1-benzyl-5-bromo-3-(1-hydroxyethylidene)indolin-2-one 
• 154225-10-2 N-(4-phenyl-1-buten-4-yl)-4-bromobenzenamine 
• 64532-41-8 O,O'-diethyl [(4-bromophenylamino)(phenyl)methyl]phosphonate 
• 73402-93-4 6-bromo-2,4-diphenylquinoline 

Relevant articles and documents

Iron-Catalyzed Oxidative Amination of Benzylic C(sp3)–H Bonds with Anilines

Iron-catalyzed oxidative amination of benzylic C(sp3)–H bonds with anilines bearing electron-withdrawing groups (EWGs) or electron-donating groups (EDGs) is realized based on simple variations of N-substituents on imidazolium cations in novel ionic Fe(III) complexes. The structural modification of the imidazolium cation resulted in regulation of the redox potential and the catalytic performance of the iron metal center. Using DTBP as oxidant, [HItBu][FeBr4] showed the highest catalytic activity for anilines bearing EWGs, while [HIPym][FeBr4] was more efficient for EDG-substituted anilines. This work provides alternative access to benzylamines with the advantages of both a wide substrate scope and iron catalysis.

Cobalt nanoclusters coated with N-doped carbon for chemoselective nitroarene hydrogenation and tandem reactions in water

The development of active and selective non-noble metal-based catalysts for the chemoselective reduction of nitro compounds in aquo media under mild conditions is an attractive research area. Herein, the synthesis of subnanometric and stable cobalt nanoclusters, covered by N-doped carbon layers as core-shell (Co@NC-800), for the chemoselective reduction of nitroarenes is reported. TheCo@NC-800catalyst was prepared by the pyrolysis of the Co(tpy)2complex impregnated on Vulcan carbon. In fact, the use of a molecular complex based on six N-Co bonds drives the formation of a well-defined and distributed cobalt core-shell nanocluster covered by N-doped carbon layers. In order to elucidate its nature, it has been fully characterized by using several advanced techniques. In addition, this as-prepared catalyst showed high activity, chemoselectivity and stability toward the reduction of nitro compounds with H2and under mild reaction conditions; water was used as a green solvent, improving the previous results based on cobalt catalysts. Moreover, theCo@NC-800catalyst is also active and selective for the one-pot synthesis of secondary aryl amines and isoindolinones through the reductive amination of nitroarenes. Finally, based on diffraction and spectroscopic studies, metallic cobalt nanoclusters with surface CoNxpatches have been proposed as the active phase in theCo@NC-800material.

Cooperative catalysis of molybdenum with organocatalysts for distribution of products between amines and imines

Multi-amino groups and nitrogen donors compound was discovered as an organocatalyst for N-alkylation of alcohols with amines in the presence of Mo(CO)6. The Mo(CO)6/organocatalyst binary system has shown to be a highly active catalyst for the N-alkylation reaction between alcohols and amines with excellent tolerance of variable starting materials bearing different functional groups. Of particular note, this method possessing a superiority selectivity in the synthesis of N-alkylated amines or imines, which can be controlled by the reaction temperature. The cooperative catalysis mechanism in combination of Mo(CO)6 with organocatalyst was elucidated by control experiments.