287935-86-8

Basic information

• Product Name: methyl 2(R,S)-benzyl-3-{hydroxy[1'(R)-(N-benzyloxycarbonylamino)ethyl]phosphinyl}propanoate
• Synonyms: methyl 2(R,S)-benzyl-3-{hydroxy[1'(R)-(N-benzyloxycarbonylamino)ethyl]phosphinyl}propanoate
• CAS NO: 287935-86-8
• Molecular Weight: 419.414
• Mol File: 287935-86-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: methyl 2(R,S)-benzyl-3-{hydroxy[1'(R)-(N-benzyloxycarbonylamino)ethyl]phosphinyl}propanoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 2(R,S)-benzyl-3-{hydroxy[1'(R)-(N-benzyloxycarbonylamino)ethyl]phosphinyl}propanoate(287935-86-8)
• EPA Substance Registry System: methyl 2(R,S)-benzyl-3-{hydroxy[1'(R)-(N-benzyloxycarbonylamino)ethyl]phosphinyl}propanoate(287935-86-8)

Safety Data

• Hazardous Substances Data: 287935-86-8(Hazardous Substances Data)

Upstream product

• 108327-37-3 [1-[[(phenylmethoxy)carbonyl]amino]ethyl]phosphinic acid 
• 3070-71-1 methyl 2-benzylacrylate 
• 115115-40-7 (R)-1-(N-benzyloxycarbonylamino)ethylphosphinic acid 

Downstream Products

• 287935-82-4 2(R,S)-benzyl-3-{hydroxy[1'(R)-(N-benzyloxycarbonylamino)ethyl]phosphinyl}propanoyl-L-tyrosine benzyl ester 
• 287935-88-0 2(R,S)-benzyl-3-{hydroxy[1'(R)-(N-benzyloxycarbonylamino)ethyl]phosphinyl}propanoyl-L-3-iodotyrosine 
• 287935-83-5 2(R,S)-benzyl-3-{hydroxy[1'(R)-(N-benzyloxycarbonylamino)ethyl]phosphinyl}propanoyl-L-3-iodotyrosine methyl ester 
• 287935-87-9 2(R,S)-benzyl-3-{hydroxy[1'(R)-(N-benzyloxycarbonylamino)ethyl]phosphinyl}propanoyl-L-tyrosine 
• 287935-84-6 2(S)-benzyl-3-[hydroxy(1'(R)-aminoethyl)phosphinyl]propanoyl-L-tyrosine 
• 287935-81-3 2(R,S)-benzyl-3-{hydroxy[1'(R)-(N-benzyloxycarbonylamino)ethyl]phosphinyl}propanoic acid 

Relevant articles and documents

Synthesis of 2(S)-benzyl-3-[hydroxy(1'(R)-amino ethyl)phosphinyl]propanoyl-L3-[125I]-iodotyrosine: A radiolabelled inhibitor of aminopeptidase N

2(S)-benzyl-3-[hydroxy(1'(R)-aminoethyl)phosphinyl]propanoyl-L-3-[125I]-iodo tyrosine was prepared from 1(R)-(N-benzyloxycarbonylamino)ethylphosphinic acid in a six step synthesis. This new iodinated compound, which is a highly efficient aminopeptidase N inhibitor (Ki = 0.95 nM), can be used for complete characterization of the biochemical and pharmacological properties of aminopeptidase N and its in vivo inhibition. A high radiochemical purity was obtained with a specific activity of 2.17 Ci/mmol at the end of the synthesis.