288086-98-6

Basic information

• Product Name: (R)-1-Boc-2-[Methoxy(Methyl)carbaMoyl]pyrrolidine
• Synonyms: (R)-1-Boc-2-[Methoxy(Methyl)carbaMoyl]pyrrolidine;(R)-tert-butyl 2-(N-Methoxy-N-MethylcarbaMoyl)pyrrolidine-1-carboxylate;(R)-tert-butyl 2-(methoxy(methyl)carbamoyl)pyrrolidine-1-carboxylate
• CAS NO: 288086-98-6
• Molecular Formula: C₁₂H₂₂N₂O₄
• Molecular Weight: 258.31408
• Mol File: 288086-98-6.mol
• Article Data: 19

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (R)-1-Boc-2-[Methoxy(Methyl)carbaMoyl]pyrrolidine(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-1-Boc-2-[Methoxy(Methyl)carbaMoyl]pyrrolidine(288086-98-6)
• EPA Substance Registry System: (R)-1-Boc-2-[Methoxy(Methyl)carbaMoyl]pyrrolidine(288086-98-6)

Safety Data

• Hazardous Substances Data: 288086-98-6(Hazardous Substances Data)

Usage

Description

(R)-1-Boc-2-[Methoxy(Methyl)carbaMoyl]pyrrolidine is a chemical compound that serves as an intermediate in the synthesis of pharmaceuticals and organic compounds. It features a molecular structure with a pyrrolidine ring, a carbamoyl group, and functional groups such as methoxy and methyl. The presence of a Boc (tert-butoxycarbonyl) protecting group enhances its reactivity and selectivity during synthesis, making it a crucial component in the production of various drugs and APIs.

Uses

Used in Pharmaceutical Synthesis:
(R)-1-Boc-2-[Methoxy(Methyl)carbaMoyl]pyrrolidine is used as an intermediate for the synthesis of various drugs and active pharmaceutical ingredients (APIs). Its versatile reactivity and stability contribute to the development of complex organic molecules and pharmaceuticals.
Used in Organic Chemistry:
In the field of organic chemistry, (R)-1-Boc-2-[Methoxy(Methyl)carbaMoyl]pyrrolidine is utilized as a building block for the creation of more complex organic molecules. Its unique molecular structure allows for further functionalization and modification, leading to the development of novel compounds with potential applications in various industries.

Upstream product

• 37784-17-1 N-(tert-butoxycarbonyl)-D-proline 
• 1117-97-1 N,0-dimethylhydroxylamine 
• 6638-79-5 N,O-dimethylhydroxylamine*hydrochloride 
• 3282-30-2 pivaloyl chloride 
• 543-27-1 isobutyl chloroformate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 344-25-2 D-Prolin 

Downstream Products

• 675185-27-0 tert-butyl (2R)-2-acetylpyrrolidine-1-carboxylate 
• 1287286-77-4 (R)-tert-butyl 2-((R)-(4-(benzyloxy)phenyl)((S)-2-phenylpropanamido)methyl)pyrrolidine-1-carboxylate 
• 1287286-79-6 (S)-N-((R)-(4-(benzyloxy)phenyl)((R)-pyrrolidin-2-yl)methyl)-2-phenylpropanamide 
• 1287286-80-9 (R)-tert-butyl 2-((R)-(4-hydroxyphenyl)((S)-2-phenylpropanamido)methyl)pyrrolidine-1-carboxylate 
• 1287286-81-0 (R)-tert-butyl 2-((R)-(4-isobutoxyphenyl)((S)-2-phenylpropanamido)methyl)pyrrolidine-1-carboxylate 
• 1287286-73-0 (S)-N-((R)-(4-isobutoxyphenyl)((R)-pyrrolidin-2-yl)methyl)-2-phenylpropanamide 
• 1287286-75-2 (R)-tert-butyl 2-(4-(benzyloxy)benzoyl)pyrrolidine-1-carboxylate 
• 1453852-55-5 (R)-tert-butyl 2-((R)-(4-chloro-3-fluorophenyl)(hydroxy)methyl)pyrrolidine-1-carboxylate 
• 1453852-57-7 (R)-tert-butyl 2-((S)-(4-chloro-3-fluorophenyl)(4-(2-(methylthio)pyrimidin-4-yl)-2-oxopyridin-1(2H)-yl)methyl)pyrrolidine-1-carboxylate 
• 1453852-53-3 (R)-tert-butyl 2-(4-chloro-3-fluorobenzoyl)pyrrolidine-1-carboxylate 

Relevant articles and documents

COMPOUNDS TARGETING RNA-BINDING PROTEINS OR RNA-MODIFYING PROTEINS

The invention relates to a compound represented by Formula (I): or a pharmaceutically acceptable salt thereof, compositions comprising the same and methods of preparing and using the same. The variables are described herein.

Development of Dual Chitinase Inhibitors as Potential New Treatment for Respiratory System Diseases

Acidic mammalian chitinase (AMCase) and chitotriosidase-1 (CHIT1) are two enzymatically active proteins produced by mammals capable of cleaving the glycosidic bond in chitin. Based on the clinical findings and animal model studies, involvement of chitinases has been suggested in several respiratory system diseases including asthma, COPD, and idiopathic pulmonary fibrosis. Exploration of structure-activity relationships within the series of 1-(3-amino-1H-1,2,4-triazol-5-yl)-piperidin-4-amines, which was earlier identified as a scaffold of potent AMCase inhibitors, led us to discover highly active dual (i.e., AMCase and CHIT1) inhibitors with very good pharmacokinetic properties. Among them, compound 30 was shown to reduce the total number of cells in bronchoalveolar lavage fluid of mice challenged with house dust mite extract after oral administration (50 mg/kg, qd). In addition, affinity toward the hERG potassium channel of compound 30 was significantly reduced when compared to the earlier reported chitinase inhibitors.

SUBSTITUTED AMINO TRIAZOLES USEFUL AS HUMAN CHITINASE INHIBITORS

Disclosed are amino triazole compounds substituted with a piperidinyl ring that is itself substituted with a heterocyclic ring. These compounds are inhibitors of acidic mammalian chitinase and chitotriosidase. Also disclosed are methods of using the compounds to treat asthma reactions caused by allergens, as well as acute and chronic inflammatory diseases, autoimmune diseases, dental diseases, neurologic diseases, metabolic diseases, liver diseases, polycystic ovary syndrome, endometriosis, and cancer.