28814-25-7

Basic information

• Product Name: 4-Chloroacridine
• Synonyms: 4-Chloroacridine
• CAS NO: 28814-25-7
• Molecular Formula: C13H8ClN
• Molecular Weight: 213.66
• Mol File: 28814-25-7.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 379.4°Cat760mmHg
• Flash Point: 215.2°C
• Appearance: /
• Density: 1.312g/cm³
• Vapor Pressure: 1.28E-05mmHg at 25°C
• Refractive Index: 1.728
• CAS DataBase Reference: 4-Chloroacridine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Chloroacridine(28814-25-7)
• EPA Substance Registry System: 4-Chloroacridine(28814-25-7)

Safety Data

• Hazardous Substances Data: 28814-25-7(Hazardous Substances Data)

Usage

InChI:InChI=1/C13H8ClN/c14-11-6-3-5-10-8-9-4-1-2-7-12(9)15-13(10)11/h1-8H

Upstream product

• 10399-73-2 acridine N-oxide 
• 260-94-6 acridine 
• 95-51-2 o-chloroaniline 
• 6630-33-7 ortho-bromobenzaldehyde 
• 64-19-7 acetic acid 

Relevant articles and documents

Preparation method of multi-functional group acridine compound and derivative thereof

The present invention relates to a preparation method of a multi-functional group acridine compound and a derivative thereof. According to the present invention, specifically a bisphosphine ligand and palladium complex catalyzed series connection coupling/cyclization reaction is used to prepare the acridine compound represented by a formula I, wherein various groups are defined in the specification; and the method has advantages of mild reaction condition, simple operation and wide substrate applicability, and the multi-functional group acridine compound and the derivative thereof can be prepared in the high yield manner. The formula I is defined in the specification.

Facile synthesis of acridines via Pd(0)-diphosphine complex-catalyzed tandem coupling/cyclization protocol

A facile and efficient approach for the synthesis of a variety of acridines via the tandem coupling/cyclization of substituted 2-bromobenzaldehydes and anilines is described. The reaction can be accomplished with ease in the presence of a catalytic amount of Pd2(dba)3 and diphosphine ligand dppf, providing a broad range of substituted acridines in good to excellent yields (up to 99%). The Lewis acid, AlCl3, is required to promote the cyclization for less electron-rich anilines.